Browsing Conditions by Author "Geddes, John R"
Now showing items 21-28 of 28
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Plasma glutathione suggests oxidative stress is equally present in early- and late- onset bipolar disorder
Singh, Nisha; McMahon, Hannah; Bilderbeck, Amy; Reed, Zoe E; Tunbridge, Elizabeth; Brett, Daniel; Geddes, John R; Goodwin, Guy M (2018-03)We previously demonstrated oxidative stress in bipolar patients and a relationship between the age of illness onset and total glutathione, a principal antioxi- dant. In this study, we sought to replicate these findings ... -
Pramipexole Enhances Reward Learning by Preserving Value Estimates
Halahakoon, Don Chamith; Geddes, John R; Cowen, Philip J; Harmer, Catherine J; Browning, Michael (2022-01)Background: Dopamine D2-like receptor agonists show promise as treatments for depression. They are thought to act by altering how individuals learn from rewarding experiences. However, the nature of these reward learning ... -
Psychosocial markers of age at onset in bipolar disorder: a machine learning approach
Joyce, Dan W; Geddes, John R; Saunders, Kate E.A. (2022-07)Bipolar disorder is a chronic and severe mental health disorder. Early stratification of individuals into subgroups based on age at onset (AAO) has the potential to inform diagnosis and early intervention. Yet, the ... -
A retrospective examination of care pathways in individuals with treatment-resistant depression
Harvey, Jade; Geddes, John R; Barrera, Alvaro (2021-05)Individuals with treatment-resistant depression (TRD) experience a high burden of illness. Current guidelines recommend a stepped care approach for treating depression, but the extent to which best-practice care pathways ... -
A signature-based machine learning model for distinguishing bipolar disorder and borderline personality disorder
Goodwin, Guy M; Geddes, John R; Saunders, Kate E.A. (2018)Mobile technologies offer new opportunities for prospective, high resolution monitoring of long-term health conditions. The opportunities seem of particular promise in psychiatry where diagnoses often rely on retrospective and ... -
Six-month Neurological and Psychiatric Outcomes in 236,379 Survivors of COVID-19
Taquet, Maxime; Geddes, John R; Harrison, Paul J (2021-01)Background. Neurological and psychiatric sequelae of COVID-19 have been reported, but there are limited data on incidence rates and relative risks. Methods. Using retrospective cohort studies and time-to-event analysis, ... -
Sleep deprivation as a treatment for major depressive episodes: A systematic review and meta-analysis
Mitter, Pamina; Geddes, John R; Cipriani, Andrea (2022-05)Sleep deprivation, alone or in combination with pharmacological treatment and as part of a chronotherapy package, is of potential use for people with major depressive episodes, however the evidence base is still conflicting. ... -
Study protocol for a randomised placebo-controlled trial of pramipexole in addition to mood stabilisers for patients with treatment resistant bipolar depression (the PAX-BD study)
Geddes, John R (2021-07)Treatment Resistant Bipolar Depression (TRBD) is a major contributor to the burden of disease associated with Bipolar Disorder (BD). Treatment options for people experiencing bipolar depression are limited to three ...