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Is there a choice to make? A pilot study investigating attitudes towards treatment in an Early Intervention for Psychosis service
(2018-03)
Purpose
The purpose of this paper is to investigate health care professionals’ (HCPs) and service-users’ (SUs) attitudes towards different treatment options in an Early Intervention for Psychosis (EIP) service as well as ...
Study of immunotherapy in antibody positive psychosis: feasibility and acceptability (SINAPPS1)
(2018-06-11)
The main finding of the SINAPPS1 study is that immunotherapy can be delivered rapidly and safely to people with acute psychosis within an acute hospital setting. The treatments were tolerated and there were no cases of ...
Prefrontal GABA levels, hippocampal resting perfusion and the risk of psychosis
(2018-01-30)
Preclinical models propose that the onset of psychosis is associated with hippocampal hyperactivity, thought to be driven by
cortical GABAergic interneuron dysfunction and disinhibition of pyramidal neurons. Recent ...
Efficacy and Acceptability of Interventions for Attenuated Positive Psychotic Symptoms in Individuals at Clinical High Risk of Psychosis: A Network Meta-Analysis
(2018-06-12)
Background: Attenuated positive psychotic symptoms represent the defining features of the clinical high-risk for psychosis (CHR-P) criteria. The effectiveness of each available treatment for reducing attenuated positive ...
Sleep Disorders in Early Psychosis: Incidence, Severity, and Association With Clinical Symptoms
(2018-09-08)
Sleep disturbance is known to be associated with psychosis, but sleep disorders (eg. insomnia, nightmare disorder, sleep apnea) have rarely been investigated. We aimed to provide the first detailed assessment of sleep ...
The Experience of Sleep Problems and Their Treatment in Young People at Ultra-High Risk of Psychosis: A Thematic Analysis
(2018-08)
We view sleep disruption as a contributory causal factor in the development of psychotic experiences. Clinical trials indicate that psychological interventions targeting insomnia result in improvements in both sleep and ...