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Autoimmune psychosis: an international consensus on an approach to the diagnosis and management of psychosis of suspected autoimmune origin
(2019-10)
There is increasing recognition in the neurological and psychiatric literature of patients with so-called isolated
psychotic presentations (ie, with no, or minimal, neurological features) who have tested positive for ...
Attitudes to physical healthcare in severe mental illness; a patient and mental health clinician qualitative interview study
(2020-11)
People with severe mental illness experience physical health significantly worse than the general population. Physical health monitoring is shared between primary care and secondary mental healthcare services, though there ...
Elevated homocysteine and N-methyl-D-aspartate-receptor antibodies as a cause of behavioural and cognitive decline in 22q11.2 deletion syndrome
(2017-12)
A 19-year-old male with 22q11.2 deletion syndrome presented with a 4-year history of cognitive decline and symptoms suggestive of atypical psychosis. Potential for elevated homocysteine and NMDA-receptor antibodies in the ...
Study of immunotherapy in antibody positive psychosis: feasibility and acceptability (SINAPPS1)
(2018-06-11)
The main finding of the SINAPPS1 study is that immunotherapy can be delivered rapidly and safely to people with acute psychosis within an acute hospital setting. The treatments were tolerated and there were no cases of ...
Intravenous immunoglobulin and rituximab versus placebo treatment of antibody-associated psychosis: study protocol of a randomised phase IIa double-blinded placebo-controlled trial (SINAPPS2)
(2019-06)
Background: Evidence is conflicting about a causal role of inflammation in psychosis and, specifically, regarding antibodies binding to neuronal membrane targets, especially N-methyl-D-aspartate receptors. NMDAR, LGI1 and ...
Measuring Disturbance of the Endocannabinoid System in Psychosis A Systematic Review and Meta-analysis
(2019-06)
Importance: The endocannabinoid system (ECS) is a lipid-based endogenous signaling system. Its relevance to psychosis is through the association between cannabis use and the onset and course of illness and through the ...
Effect of point of care blood testing on physical health check completion in mental health services: mixed-methods evaluation
(2020-10)
Physical health outcomes in severe mental illness are worse than in the general population. Routine physical health check completion in this group is poor.
Aims
To quantitatively and qualitatively evaluate the impact of ...
The Early Youth Engagement in first episode psychosis (EYE-2) study: pragmatic cluster randomised controlled trial of implementation, effectiveness and cost-effectiveness of a team-based motivational engagement intervention to improve engagement
(2021-04)
Background
Early Intervention in Psychosis (EIP) services improve health outcomes for young people with psychosis in the medium–long term, but 25% of young people disengage in the first 12 months with costs to their mental ...
Brain glutamate concentration in men with early psychosis: a magnetic resonance spectroscopy case–control study at 7 T
(2021-06)
Abnormalities in glutamate neurotransmission are linked to psychotic symptoms and cognitive dysfunction in schizophrenia. magnetic resonance spectroscopy (MRS) provides an acceptable means of measuring glutamate in the ...
Violent outcomes in first-episode psychosis: A clinical cohort study
(2019-11)
Aim
Violence risk is an important part of a comprehensive clinical assessment in first‐episode psychosis. This study addresses limitations of previous violent outcome research in first‐episode psychosis, which has typically ...