Browsing Schizophrenia and Psychotic Disorders by Author "Harrison, Paul J"
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CACNA1C (CaV1.2) and other L-type calcium channels in the pathophysiology and treatment of psychiatric disorders: Advances from functional genomics and pharmacoepidemiology
Harrison, Paul J; Colbourne, Lucy; Mould, Arne; Tunbridge, Elizabeth (2022-09)A role for voltage-gated calcium channels (VGCCs) in psychiatric disorders has long been postulated as part of a broader involvement of intracellular calcium signalling. However, the data were inconclusive and hard to ... -
Cognitive Behavioural Therapy for Nightmares for Patients with Persecutory Delusions (Nites): An Assessor-Blind, Pilot Randomized Controlled Trial
Sheaves, Bryony; Waite, Felicity; Harrison, Paul J; Freeman, Daniel (2019-05)Objective:Nightmares are relatively common in patients experiencing psychosis but rarely assessed or treated. Nightmares may maintain persecutory delusions by portraying fears in sensory-rich detail. We tested the potential ... -
GRIN2A (NR2A): a gene contributing to glutamatergic involvement in schizophrenia
Harrison, Paul J (2023-09)Involvement of the glutamate system, particularly N-methyl-D-aspartate (NMDA) receptor hypofunction, has long been postulated to be part of the pathophysiology of schizophrenia. An important development is provided by ... -
New drug targets in psychiatry: Neurobiological considerations in the genomics era
Harrison, Paul J; Mould, Arne; Tunbridge, Elizabeth (2022-07)After a period of withdrawal, pharmaceutical companies have begun to reinvest in neuropsychiatric disorders, due to improvements in our understanding of these disorders, stimulated in part by genomic studies. However, ... -
Sleep disturbance and psychiatric disorders
Freeman, Daniel; Sheaves, Bryony; Waite, Felicity; Harrison, Paul J (2020-07)Signs of mental ill health that cut across psychiatric diagnostic categories at high rates are typically viewed as non-specific occurrences, downgraded in importance and disregarded. However, problems not associated with ...