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Subclinical anxiety and depression are associated with deficits in attentional target facilitation, not distractor inhibition
(2019-06)
Mood and anxiety disorders are associated with deficits in attentional control
involving emotive and non-emotive stimuli. Current theories focus on impaired
attentional inhibition of distracting stimuli in producing these ...
Value of monitoring negative emotional bias in primary care in England for personalised antidepressant treatment: a modelling study
(2019-11)
Depressed patients often focus on negative life events. Effective antidepressant therapy reverses this negative emotional bias (NEB) within 1 week. Clinical therapeutic effect usually requires 4–6 weeks. The value of ...
Attentional bias modification is associated with fMRI response toward negative stimuli in individuals with residual depression: a randomized controlled trial
(2019-08)
BACKGROUND:Attentional bias modification (ABM) may lead to more adaptive emotion perception and emotion regulation. Understanding the neural basis of these effects may lead to greater precision for the development of future ...
Cognitive neuropsychological theory of antidepressant action: a modern-day approach to depression and its treatment
(2020-01)
Depression is a leading cause of disability worldwide and improving its treatment is a core research priority for future programmes. A change in the view of psychological and biological processes, from seeing them as ...
Effect of the NMDA receptor partial agonist, d-cycloserine, on emotional processing and autobiographical memory
(2020-04)
Background: Studies suggest that d-cycloserine (DCS) may have antidepressant potential through its interaction with the glycine site of the N-Methyl-D-aspartate receptor (NMDAR); however clinical evidence of DCS’s efficacy ...
Cognition in Mood Disorders
(2020-01)
Mood disorders are common, complex, and one of the main causes of morbidity worldwide (1).
There has been an increasing recognition that cognitive dysfunction is a central aspect of most
mood disorders, as well as being ...
A single administration of ‘microbial’ D-alanine to healthy volunteers augments reaction to negative emotions: a comparison with D-serine
(2020-03)
Background Activation of the glutamate N-methyl-D-Aspartate receptor (NMDAR) with its co-agonist D-serine has been shown to improve subjective mood in healthy volunteers. D-alanine is another potent NMDAR co-agonist which ...
Neural effects of a single dose of fluoxetine on resting-state functional connectivity in adolescent depression
(2020-11)
Fluoxetine is commonly prescribed in adolescent depression, but the neural mechanisms underlying its action remain poorly understood. Here, we used resting-state functional magnetic resonance imaging to investigate the ...
Precision biomarkers for mood disorders based on brain imaging
(2020-10)
Mood disorders are a global public health problem because of their high prevalence, chronicity, and recurrence throughout the lifespan as well as increased risk of mortality.123 They also impose a heavy economic burden on ...
Glucocorticoid ultradian rhythmicity differentially regulates mood and resting state networks in the human brain: A randomised controlled clinical trial
(2021-02)
Adrenal glucocorticoid secretion into the systematic circulation is characterised by a complex rhythm, composed of the diurnal variation, formed by changes in pulse amplitude of an underlying ultradian rhythm of short ...