Browsing Depressive Disorders by Author "Harmer, Catherine J"
Now showing items 1-20 of 36
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Accuracy in recognising happy facial expressions is associated with antidepressant response to a NOP receptor antagonist but not placebo treatment
Browning, Michael; Harmer, Catherine J (2021-10)Background: Clinical trials with putative antidepressants can be difficult to execute as it can take up to 8 weeks before differences emerge between drug and placebo, and long expensive trials often fail. Implementation ... -
Acute neural effects of fluoxetine on emotional regulation in depressed adolescents
Capitao, Liliana; Chapman, Robert; Wright, Lucy C; Murphy, Susannah E; James, Anthony; Cowen, Philip J; Harmer, Catherine J (2022-05)Adolescent major depressive disorder (MDD) is associated with disrupted processing of emotional stimuli and difficulties in cognitive reappraisal. Little is known however about how current pharmacotherapies act to modulate ... -
Attentional bias modification is associated with fMRI response toward negative stimuli in individuals with residual depression: a randomized controlled trial
Browning, Michael; Harmer, Catherine J (2019-08)BACKGROUND:Attentional bias modification (ABM) may lead to more adaptive emotion perception and emotion regulation. Understanding the neural basis of these effects may lead to greater precision for the development of future ... -
Catechol-O-methyltransferase activity does not influence emotional processing in men
Martens, M A G; Scaife, Jessica; Harmer, Catherine J; Harrison, Paul J; Tunbridge, Elizabeth (2022-04)Background: Catechol-O-methyltransferase (COMT) regulates cortical dopaminergic transmission and prefrontal-dependent cognitive function. However, its role in other cognitive processes, including emotional processing, is ... -
Cognition in Mood Disorders
Oyesanya, Mayowa; Harmer, Catherine J (2020-01)Mood disorders are common, complex, and one of the main causes of morbidity worldwide (1). There has been an increasing recognition that cognitive dysfunction is a central aspect of most mood disorders, as well as being ... -
Cognitive neuropsychological theory of antidepressant action: a modern-day approach to depression and its treatment
Godlewska, Beata R; Harmer, Catherine J (2020-01)Depression is a leading cause of disability worldwide and improving its treatment is a core research priority for future programmes. A change in the view of psychological and biological processes, from seeing them as ... -
Cognitive predictors of stress-induced mood malleability in depression
Harmer, Catherine J (2023-09)Basic attentional control, negative biases in attention and interpretation, and rumination are all cognitive processes associated with depression; however, less is known about their predictive role in depressive mood ... -
A continuum hypothesis of psychotomimetic rapid antidepressants
Harmer, Catherine J; Tamm, Sandra (2021-05)Ketamine, classical psychedelics and sleep deprivation are associated with rapid effects on depression. Interestingly, these interventions also have common psychotomimetic actions, mirroring aspects of psychosis such as ... -
A Dissociation of the Acute Effects of Bupropion on Positive Emotional Processing and Reward Processing in Healthy Volunteers
Walsh, Annabel E L; Browning, Michael; Cowen, Philip J; Harmer, Catherine J (2018-10)Background: Previous research indicates that antidepressants can restore the balance between negative and positive emotional processing early in treatment, indicating a role of this effect in later mood improvement. However, ... -
Effect of acute citalopram on self-referential emotional processing and social cognition in healthy volunteers
Murphy, Susannah E; Wright, Lucy C; Carson, James; Van Assche, Indra; O'Brien, Jessica; Oyesanya, Mayowa; Harmer, Catherine J (2020-10)Background Depression is characterised by negative views of the self. Antidepressant treatment may remediate negative self-schema through increasing processing of positive information about the self. Changes in affective ... -
The effect of sertraline on emotional processing: secondary analyses of the PANDA randomised controlled trial
Harmer, Catherine J (2021-01)Background. According to the cognitive neuropsychological model, antidepressants reduce symptoms of depression and anxiety by increasing positive relative to negative information processing. Most studies of whether ... -
Effect of the NMDA receptor partial agonist, d-cycloserine, on emotional processing and autobiographical memory
Harmer, Catherine J; Cowen, Philip J (2020-04)Background: Studies suggest that d-cycloserine (DCS) may have antidepressant potential through its interaction with the glycine site of the N-Methyl-D-aspartate receptor (NMDAR); however clinical evidence of DCS’s efficacy ... -
An Experimental Medicine Investigation of the Effects of Subacute Pramipexole Treatment on Emotional Information Processing in Healthy Volunteers
Cowen, Philip J; Harmer, Catherine J; Browning, Michael; Halahakoon, Don Chamith (2021-08)Treatment with the dopamine D2/D3 receptor agonist pramipexole has demonstrated promising clinical effects in patients with depression. However, the mechanisms through which pramipexole might alleviate depressive symptoms ... -
An Experimental Medicine Investigation of the Effects of Subacute Pramipexole Treatment on Emotional Information Processing in Healthy Volunteers
Halahakoon, Don Chamith; Browning, Michael; Cowen, Philip J; Harmer, Catherine J (2021-08)Treatment with the dopamine D2/D3 receptor agonist pramipexole has demonstrated promising clinical effects in patients with depression. However, the mechanisms through which pramipexole might alleviate depressive symptoms ... -
Glucocorticoid ultradian rhythmicity differentially regulates mood and resting state networks in the human brain: A randomised controlled clinical trial
Harmer, Catherine J (2021-02)Adrenal glucocorticoid secretion into the systematic circulation is characterised by a complex rhythm, composed of the diurnal variation, formed by changes in pulse amplitude of an underlying ultradian rhythm of short ... -
The knowns and unknowns of SSRI treatment in young people with depression and anxiety: efficacy, predictors, and mechanisms of action
Murphy, Susannah E; Capitao, Liliana; Cowen, Philip J; Harmer, Catherine J (2021-08)The use of SSRIs for the treatment of depression and anxiety in young people is increasing. However, the effects of SSRIs in adolescence, a time when there are substantial changes in neural, cognitive, and social functioning, ... -
Machine learning prediction will be part of future treatment of depression
Harmer, Catherine J (2023-02)Machine learning (ML) is changing the way that medicine is practiced. While already clinically utilised in diagnostic radiology and outcome prediction in intensive care unit, ML approaches in psychiatry remain nascent. ... -
Neural effects of a single dose of fluoxetine on resting-state functional connectivity in adolescent depression
Capitao, Liliana; Chapman, Robert; Wright, Lucy C; Murphy, Susannah E; James, Anthony; Cowen, Philip J; Harmer, Catherine J (2020-11)Fluoxetine is commonly prescribed in adolescent depression, but the neural mechanisms underlying its action remain poorly understood. Here, we used resting-state functional magnetic resonance imaging to investigate the ... -
No antidepressant-like acute effects of bright light on emotional information processing in healthy volunteers
Harmer, Catherine J; Zghoul, Tarek; Cowen, Philip J (2021-11)Rationale: Bright light treatment (BLT) is an efficacious antidepressant intervention, but its mechanism of action is not well understood. Antidepressant drugs acutely affect how emotional information is processed, pushing ... -
No Association Between Amygdala Responses to Negative Faces and Depressive Symptoms: Cross-Sectional Data from 28,638 Individuals in the UK Biobank Cohort
Harmer, Catherine J; Tamm, Sandra (2022-07)In this Priority Data Letter, we report on the largest study to date to test the association between amygdala reactivity and depressive symptoms based on UK Biobank data. For transparency, we initially set out to investigate ...