Browsing Depressive Disorders by Author "Cowen, Philip J"
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Acute neural effects of fluoxetine on emotional regulation in depressed adolescents
Capitao, Liliana; Chapman, Robert; Wright, Lucy C; Murphy, Susannah E; James, Anthony; Cowen, Philip J; Harmer, Catherine J (2022-05)Adolescent major depressive disorder (MDD) is associated with disrupted processing of emotional stimuli and difficulties in cognitive reappraisal. Little is known however about how current pharmacotherapies act to modulate ... -
A Dissociation of the Acute Effects of Bupropion on Positive Emotional Processing and Reward Processing in Healthy Volunteers
Walsh, Annabel E L; Browning, Michael; Cowen, Philip J; Harmer, Catherine J (2018-10)Background: Previous research indicates that antidepressants can restore the balance between negative and positive emotional processing early in treatment, indicating a role of this effect in later mood improvement. However, ... -
Effect of the NMDA receptor partial agonist, d-cycloserine, on emotional processing and autobiographical memory
Harmer, Catherine J; Cowen, Philip J (2020-04)Background: Studies suggest that d-cycloserine (DCS) may have antidepressant potential through its interaction with the glycine site of the N-Methyl-D-aspartate receptor (NMDAR); however clinical evidence of DCS’s efficacy ... -
An Experimental Medicine Investigation of the Effects of Subacute Pramipexole Treatment on Emotional Information Processing in Healthy Volunteers
Cowen, Philip J; Harmer, Catherine J; Browning, Michael; Halahakoon, Don Chamith (2021-08)Treatment with the dopamine D2/D3 receptor agonist pramipexole has demonstrated promising clinical effects in patients with depression. However, the mechanisms through which pramipexole might alleviate depressive symptoms ... -
An Experimental Medicine Investigation of the Effects of Subacute Pramipexole Treatment on Emotional Information Processing in Healthy Volunteers
Halahakoon, Don Chamith; Browning, Michael; Cowen, Philip J; Harmer, Catherine J (2021-08)Treatment with the dopamine D2/D3 receptor agonist pramipexole has demonstrated promising clinical effects in patients with depression. However, the mechanisms through which pramipexole might alleviate depressive symptoms ... -
Fifty years on: Serotonin and depression
Cowen, Philip J; Browning, Michael (2023-03)It has been over 50 years since the original serotonin hypothesis was proposed by the British Psychiatrist Alec Coppen. Recently, some authors have questioned the validity of the hypothesis. In this narrative review, we ... -
The knowns and unknowns of SSRI treatment in young people with depression and anxiety: efficacy, predictors, and mechanisms of action
Murphy, Susannah E; Capitao, Liliana; Cowen, Philip J; Harmer, Catherine J (2021-08)The use of SSRIs for the treatment of depression and anxiety in young people is increasing. However, the effects of SSRIs in adolescence, a time when there are substantial changes in neural, cognitive, and social functioning, ... -
A leaky umbrella has little value: evidence clearly indicates the serotonin system is implicated in depression
Browning, Michael; Goodwin, Guy M; McCutcheon, Robert A; Cowen, Philip J (2023-06)A recent “umbrella” review examined various biomarkers relating to the serotonin system, and concluded there was no consistent evidence implicating serotonin in the pathophysiology of depression. We present reasons for why ... -
Neural effects of a single dose of fluoxetine on resting-state functional connectivity in adolescent depression
Capitao, Liliana; Chapman, Robert; Wright, Lucy C; Murphy, Susannah E; James, Anthony; Cowen, Philip J; Harmer, Catherine J (2020-11)Fluoxetine is commonly prescribed in adolescent depression, but the neural mechanisms underlying its action remain poorly understood. Here, we used resting-state functional magnetic resonance imaging to investigate the ... -
No antidepressant-like acute effects of bright light on emotional information processing in healthy volunteers
Harmer, Catherine J; Zghoul, Tarek; Cowen, Philip J (2021-11)Rationale: Bright light treatment (BLT) is an efficacious antidepressant intervention, but its mechanism of action is not well understood. Antidepressant drugs acutely affect how emotional information is processed, pushing ... -
No benefit from flexible titration above minimum licensed dose in prescribing antidepressants for major depression: systematic review
Cowen, Philip J; Cipriani, Andrea (2019-12)Background In fixed‐dose antidepressant trials, the lower range of the licensed dose achieves the optimal balance between efficacy and tolerability. Whether flexible upward titration while side‐effects permit provides ... -
An online experimental medicine trial on the effect of 28-day simvastatin administration on emotional processing, reward learning, working memory and salivary cortisol in healthy volunteers at risk for depression: OxSTEP protocol
Di Giorgi, Riccardo; Cowen, Philip J (2023-06)Background: Evidence suggests inflammation may be a key mechanism by which psychosocial stress, including loneliness, predisposes to depression. Observational and clinical studies have suggested simvastatin, with its ... -
Pramipexole Enhances Reward Learning by Preserving Value Estimates
Halahakoon, Don Chamith; Geddes, John R; Cowen, Philip J; Harmer, Catherine J; Browning, Michael (2022-01)Background: Dopamine D2-like receptor agonists show promise as treatments for depression. They are thought to act by altering how individuals learn from rewarding experiences. However, the nature of these reward learning ... -
Predicting treatment response in depression: the role of anterior cingulate cortex
Godlewska, Beata R; Browning, Michael; Cowen, Philip J; Harmer, Catherine J (2018)Background: Identification of biomarkers predicting therapeutic outcome to antidepressant treatment is one of the most important tasks in current research because it may transform the lengthy process of finding the right ... -
A single dose of fluoxetine reduces neural limbic responses to anger in depressed adolescents
Capitao, Liliana; Chapman, Robert; Murphy, Susannah E; James, Anthony; Cowen, Philip J; Harmer, Catherine J (2019-01-21)Depression in adolescence is frequently characterised by symptoms of irritability. Fluoxetine is the antidepressant with the most favourable benefit:risk ratio profile to treat adolescent depression, but the neural ... -
Statins for major depressive disorder: A systematic review and meta-analysis of randomized controlled trials
De Giorgi, Riccardo; De Crescenzo, Franco; Cowen, Philip J; Harmer, Catherine J (2021-03)The burden of depressive disorder is large and new treatment approaches are required. Repurposing widely available drugs such as statins may be a time- and cost-effective solution. Statins have anti-inflammatory and ... -
Statins in depression: a repurposed medical treatment can provide novel insights in mental health
De Giorgi, Riccardo; Cowen, Philip J; Harmer, Catherine J (2022-08)Depression has a large burden, but the development of new drugs for its treatment has proved difficult. Progresses in neuroscience have highlighted several physiopathological pathways, notably inflammatory and metabolic ... -
Stress, inflammation and hippocampal subfields in depression: A 7 Tesla MRI Study
Cowen, Philip J; Godlewska, Beata R (2020-02)Experiencing stressful events throughout one’s life, particularly childhood trauma, increases the likelihood of being diagnosed with Major Depressive Disorder (MDD). Raised levels of cortisol, and markers of inflammation ... -
Subchronic treatment with St John’s wort produces a positive shift in emotional processing in healthy volunteers
Cowen, Philip J; Harmer, Catherine J (2018-11-28)The neurocognitive model of antidepressant treatment in depression states that antidepressants work by producing relatively immediate positive shifts in emotional processing, which translate into clinical improvement with ... -
Translating the promise of 5HT4 receptor agonists for the treatment of depression
Murphy, Susannah E; De Cates, Angharad N; Gillespie, Amy L; Godlewska, Beata R; Scaife, Jessica; Wright, Lucy C; Cowen, Philip J; Harmer, Catherine J (2020-02)Animal experimental studies suggest that 5-HT4 receptor activation holds promise as a novel target for the treatment of depression and cognitive impairment. 5-HT4 receptors are postsynaptic receptors that are located in ...