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    A feasibility study to determine whether the daily consumption of flavonoid-rich pure cocoa has the potential to reduce fatigue and fatigability in people with Parkinson's (pwP)

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    Date
    2022-01
    Author
    Dawes, Helen
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    Citation
    S. Coe, D. Andreoli, M. George, J. Collett, A. Reed, J. Cossington, H. Izadi, A. Dixon, M. Mansoubi, H. Dawes, A feasibility study to determine whether the daily consumption of flavonoid-rich pure cocoa has the potential to reduce fatigue and fatigability in people with Parkinson's (pwP), Clinical Nutrition ESPEN, Volume 48, 2022, Pages 68-73,
    Abstract
    Summary Flavonoids, plant compounds found in certain foods, may have the ability to improve fatigue and fatigability. However, to date, no well-designed intervention studies assessing the role of flavonoid consumption for fatigue management in people with Parkinson's (pwP) have been performed. Objectives To determine the feasibility and estimate potential effect of flavonoid-rich cocoa on fatigue and fatigability in pwP. Methods This was a randomised (1:1) double-blind placebo controlled feasibility study in which 30 pwP were recruited from the European Parkinson Therapy Centre, Italy (trial registration: NCT03288155). During a six day intervention participants consumed a high (10.79 mg/g) or low flavonoid cocoa (1.02 mg/g) beverage (18 g Cocoa with 200 ml Rice milk) once daily. Potential effect on fatigue and fatigability was measured (baseline to day 6). Feasibility and fidelity were assessed through recruitment and retention, adherence and a process evaluation. Results From July 2017 to May 2018, 30 pwP were recruited and randomised and allocated to high (n = 15) or low (n = 15) flavonoid groups and included in analysis. Missing data was less than 5% and adherence to intervention of all allocated individuals was 97%. There was a small effect on fatigability (6 min walk test: ES 0.11 (95%CI = −0.11-0.26); Z = 0.81). There were two adverse events (one in the control and one in the intervention group). Conclusion The consumption of cocoa is feasible and well received in pwP, and further investigation on the effect on fatigability is warranted.
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    URI
    https://oxfordhealth-nhs.archive.knowledgearc.net/handle/123456789/1042
    Published online at:
    https://doi.org/10.1016/j.clnesp.2022.01.023
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