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Now showing items 21-30 of 48
The NICE Evidence Standards Framework for digital health and care technologies – Developing and maintaining an innovative evidence framework with global impact
(2021-06)
Objective: In 2018, the UK National Institute for Health and Care Excellence (NICE), in partnership with Public Health
England, NHS England, NHS Improvement and others, developed an evidence standards framework (ESF) for ...
Risk Factors for Mobility Decline in Community-Dwelling Older Adults: A Systematic Literature Review
(2021-08)
Mobility is essential to maintaining independence for older adults. This systematic review aimed to summarize evidence about
self-reported risk factors for self-reported mobility decline; and to provide an overview of ...
Ethics of Early Intervention in Alzheimer’s Disease
(2021-03)
Alzheimer’s disease (AD) research, treatment, and prevention focus increasingly on developing personalized interventions based on personal genetic, biological, phenotypic data, for
early intervention (EI) to limit harm. ...
Multi-scale neural signatures of major depressive, anxiety, and stress-related disorders
(2021-07)
The extent of shared and distinct neural mechanisms underlying major depressive disorder (MDD), anxiety and stress-related disorders is still unclear. We compared the neural signatures of these disorders in 5,405 UK Biobank ...
Changes to management of hypertension in pregnancy, and attitudes to self-management: An online survey of obstetricians, before and following the first wave of the COVID-19 pandemic
(2021-12)
Objective
This study aimed to understand the views and practice of obstetricians regarding self-monitoring for hypertensive disorders of pregnancy (blood pressure (BP) and proteinuria), the potential for self-management ...
Online peer support training to promote adolescents’ emotional support skills, mental health and agency during COVID-19: A pilot randomised controlled trial
(2021-08)
Background: Adolescents often look to their peers for emotional support, so it is critical that they are prepared to take on a supportive role, especially during a health crisis. Using a pilot randomised controlled trial ...
Quantification of allosteric communications in matrix metalloprotease-1 on alpha-synuclein aggregates and substratedependent virtual screening
(2021-01)
Alpha-synuclein (aSyn) has implications in pathological protein aggregations observed in
neurodegenerative disorders, including Parkinson's and Alzheimer's diseases. There are currently
no approved prevention and cure ...
Bilateral Permanent Childhood Hearing Loss and Health-Related Quality of Life in Adolescence
(2021-06)
Little is known about the impact of bilateral permanent childhood hearing loss (PCHL) on
health-related quality of life (HRQoL). The objective of this study was to describe preference-based
and non-preference based HRQoL ...
Exploring The Use of Health and Wellbeing Measures During Pregnancy and The First Year Following Birth in Women Living With Pre-Existing Long-Term Conditions: Qualitative Interviews With Women and Healthcare Professionals
(2021-02)
Background
One way in which care for pregnant and postpartum women living with long-term health conditions (LTCs) may be improved is through the adoption of standardised measures to provide evidence of health outcomes and ...
Elevated iron concentration in putamen and cortical speech motor network in developmental stuttering.
(2021-07)
Theoretical accounts of developmental stuttering implicate dysfunctional cortico-striatalthalamo-cortical motor loops through the putamen. Analysis of conventional MRI brain scans
in people who stutter has failed to yield ...