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Now showing items 11-20 of 24
Identifying outcomes for depression that matter to patients, informal caregivers, and health-care professionals: qualitative content analysis of a large international online survey
(2020-07)
Many clinical trials have assessed treatments for depressive disorders and bipolar depression. However, whether, and which, assessed outcome domains really matter to patients, informal caregivers, and health-care professionals ...
Neural effects of a single dose of fluoxetine on resting-state functional connectivity in adolescent depression
(2020-11)
Fluoxetine is commonly prescribed in adolescent depression, but the neural mechanisms underlying its action remain poorly understood. Here, we used resting-state functional magnetic resonance imaging to investigate the ...
Associations between statin use and suicidality, depression, anxiety, and seizures: a Swedish total-population cohort study
(2020-11)
Background
Statins have shown both protective and adverse associations with neuropsychiatric outcomes. We aimed to examine the possible associations between statins and suicidality, depression, anxiety, and seizures.
M ...
Effect of acute citalopram on self-referential emotional processing and social cognition in healthy volunteers
(2020-10)
Background
Depression is characterised by negative views of the self.
Antidepressant treatment may remediate negative self-schema
through increasing processing of positive information about the
self. Changes in affective ...
Online mood monitoring in treatment-resistant depression: qualitative study of patients' perspectives in the NHS
(2020-01)
Aims and method True Colours is an automated symptom monitoring programme
used by National Health Service psychiatric services. This study explored whether
patients with unipolar treatment-resistant depression (TRD) found ...
Mood Homeostasis, Low Mood, and History of Depression in 2 Large Population Samples
(2020-04)
Importance Existing therapeutic options are insufficient to tackle the disease burden of depression, and new treatments are sorely needed. Defining new psychotherapeutic targets is challenging given the paucity of coherent ...
Antidepressants plus benzodiazepines in major depressive disorder: a clinical dilemma with no recent answers from research
(2020-10)
Comorbid anxiety symptoms are common in depression, and adding benzodiazepines to antidepressant treatment may seem a rational clinical solution. Benzodiazepines also have potential to reduce the initial anxiety that may ...
How effective is augmentation with psychotherapy as a next-step option for treatment-resistant depression?
(2020-08)
Determining the optimum next-step treatment for the numerous patients with depression who do not adequately respond to an initial trial of medication remains a source of uncertainty in clinical practice. Although a number ...
Insomnia as a mediating therapeutic target for depressive symptoms: A sub-analysis of participant data from two large randomized controlled trials of a digital sleep intervention
(2020-06)
Insomnia predicts the onset of depression, commonly co-presents with depression
and often persists following depression remission. However, these conditions can
be challenging to treat concurrently using depression-specific ...
The effectiveness of interventions aimed at improving wellbeing and resilience to stress in first responders: A systematic review
(2020-07)
First responders are routinely exposed to traumatic critical incidents, placing them at higher risk for developing stress-related psychopathology and associated health problems than the general population. Interventions ...