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Now showing items 111-116 of 116
Translating the promise of 5HT4 receptor agonists for the treatment of depression
(2020-02)
Animal experimental studies suggest that 5-HT4 receptor activation holds promise as a novel
target for the treatment of depression and cognitive impairment. 5-HT4 receptors are postsynaptic
receptors that are located in ...
Pro-dopaminergic pharmacological interventions for anhedonia in depression: protocol for a living systematic review of human and non-human studies
(2023-10)
Anhedonia is a key symptom of depression, and it has been suggested as a potential target for future individualised treatments. However, much is unknown about how interventions enhancing dopaminergic pathways may affect ...
Pramipexole for the Treatment of Depression: Efficacy and Mechanisms
(2023-11)
Dopaminergic mechanisms are a plausible treatment target for patients with clinical depression but are relatively underexplored in conventional antidepressant medications. There is continuing interest in the potential ...
Towards precision in the diagnostic profiling of patients: leveraging symptom dynamics in the assessment of major depressive disorder
(2023-08)
Major depressive disorder (MDD) is a heterogeneous mental disorder. International guidelines present overall symptom severity as the key dimension for clinical characterisation. However, additional layers of individual ...
Cognitive predictors of stress-induced mood malleability in depression
(2023-09)
Basic attentional control, negative biases in attention and interpretation, and rumination are all cognitive processes associated with depression; however, less is known about their predictive role in depressive mood ...
Adapted problem adaptation therapy for depression in mild to moderate Alzheimer's disease dementia: A randomized controlled trial
(2024-03)
Introduction: Trials of effectiveness of treatment options for depression in dementia are an important priority.
Methods: Randomized controlled trial to assess adapted Problem Adaptation Therapy (PATH) for depression in ...