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An online experimental medicine trial on the effect of 28-day simvastatin administration on emotional processing, reward learning, working memory and salivary cortisol in healthy volunteers at risk for depression: OxSTEP protocol
(2023-06)
Background: Evidence suggests inflammation may be a key mechanism by which psychosocial stress, including loneliness, predisposes to depression. Observational and clinical studies have suggested simvastatin, with its ...
A leaky umbrella has little value: evidence clearly indicates the serotonin system is implicated in depression
(2023-06)
A recent “umbrella” review examined various biomarkers relating to the serotonin system, and concluded there was no consistent evidence implicating serotonin in the pathophysiology of depression. We present reasons for why ...
Predicting Antidepressant Treatment Response Using Functional Brain Controllability Analysis
(2023-03)
Introduction: For decades, predicting response to the antidepressant medication has been a critical unmet need in depression treatment in clinic, and a technical challenge in depression research.
Methods: In this study, ...
Effects of escitalopram therapy on functional brain controllability in major depressive disorder
(2022-04)
Antidepressant drugs are the mainstay of treatment for patients with major depressive disorders (MDD). Given the critical role of the underlying neural control mechanism in the physiopathology of depression, this study ...
Mortality in psychotic depression: 18-year follow-up study
(2022-10)
Background
Evidence on the role of co-occurring psychiatric disorders in mortality associated with psychotic depression is limited.
Aims
To estimate the risk of cause-specific mortality in psychotic depression compared ...
Examining the Effectiveness of Web-Based Interventions to Enhance Resilience in Health Care Professionals: Systematic Review
(2022-07)
Background: Internationally, the impact of continued exposure to workplace environmental and psychological stressors on
health care professionals’mental health is associated with increased depression, substance misuse, ...
A co-produced online cultural experience compared to a typical museum website for mental health in people aged 16-24: A proof-of-principle randomised controlled trial
(2022-09)
Objective: We aimed to compare a co-produced online intervention encompassing the diverse human stories behind art and artefacts, named Ways of Being (WoB), with a typical museum website, the Ashmolean (Ash) on negative ...
Childhood determinants of past-year anxiety and depression in recently transitioned military personnel
(2020-05)
Background: Anxiety and depression may hamper a smooth transition from military to civilian life and may be important predictors of longer-term health and functioning. However, it is as yet unclear to what extent they are ...
Effect of selective serotonin reuptake inhibitor treatment following diagnosis of depression on suicidal behaviour risk: a target trial emulation
(2023-07)
There is concern regarding the impact of selective serotonin reuptake inhibitors (SSRIs) on suicidal behaviour. Using the target trial framework, we investigated the effect on suicidal behaviour of SSRI treatment following ...
Characterization of the central nervous system penetrant and selective purine P2X7 receptor antagonist JNJ-54175446 in patients with major depressive disorder
(2023-07)
JNJ-54175446 is a selective purine P2X7 receptor (P2X7R) antagonist that attenuates microglial IL-1β/IL-18 release. In healthy volunteers, JNJ-54175446 suppressed peripheral interleukin (IL)-1β release, and attenuated ...