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Now showing items 111-120 of 147
Signal variance-based collateral index in DSC perfusion: A novel method to assess leptomeningeal collateralization in acute ischaemic stroke
(2019-02)
As a determinant of the progression rate of the ischaemic process in acute large-vessel stroke, the degree of collateralization is a strong predictor of the clinical outcome after reperfusion therapy and may influence ...
CSF1R inhibitor JNJ-40346527 attenuates microglial proliferation and neurodegeneration in P301S mice
(2019-08)
Neuroinflammation and microglial activation are significant processes in Alzheimer’s disease pathology. Recent genome-wide association studies have highlighted multiple immune-related genes in association with Alzheimer’s ...
Minocycline at 2 Different Dosages vs Placebo for Patients With Mild Alzheimer Disease A Randomized Clinical Trial
(2019-11)
IMPORTANCE There are no disease-modifying treatments for Alzheimer disease (AD), the
most common cause of dementia. Minocycline is anti-inflammatory, protects against the toxic
effects of β-amyloid in vitro and in animal ...
Associations between the household environment and stunted child growth in rural India: a cross-sectional analysis
(2019-03)
Stunting is a major unresolved and growing health issue for India. Yet there remains scant evidence for the development and application of integrated, multifactorial child health interventions across India’s most rural ...
The Oxford study of Calcium channel Antagonism, Cognition, Mood instability and Sleep (OxCaMS): study protocol for a randomised controlled, experimental medicine study
(2019-02)
Background:
The discovery that voltage-gated calcium channel genes such as CACNA1C are part of the aetiology of psychiatric disorders has rekindled interest in the therapeutic potential of L-type calcium channel (LTCC) ...
Are People Ready for Personalized Brain Health? Perspectives of Research Participants in the Lifebrain Consortium
(2019-11)
Background and Objectives
A healthy brain is central to physical and mental well-being. In this multi-site, qualitative study, we investigated views and attitudes of adult participants in brain research studies on the ...
Impulse control disorders in Parkinson disease and RBD
(2019-10)
Objective
To describe the prevalence, natural history, and risk factors for impulse control behaviors
(ICBs) among people with Parkinson disease (PD), those with REM sleep behavior disorder
(RBD), and controls.
Metho ...
Effects of ketamine treatment on suicidal ideation: a qualitative study of patients’ accounts following treatment for depression in a UK ketamine clinic
(2019-08)
Objective It is recognised that ketamine treatment can
reduce suicidal ideation (SI) in people with depression, at
least in the short term. However, information is lacking on
patients’ perspectives on such effects. ...
Effects of patient suicide on psychiatrists: survey of experiences and support required
(2019-03)
Aims and method Death of patients by suicide can have powerful effects on
psychiatrists. We report the findings of a survey completed by 174 psychiatrists on
the effects of patient suicide on their emotional well-being ...
Characteristics of people with pressure ulcers using one year's routinely collected data in a defined diverse community
(2019-09)
Objective:To determine if meaningful patient characteristics pertaining to pressure ulcers (PU) can be derived from routinely collected community health data.
Methods: A retrospective cohort analysis of records was carried ...