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dc.contributor.authorHarmer, Catherine J
dc.contributor.authorZghoul, Tarek
dc.contributor.authorCowen, Philip J
dc.identifier.citationAlexander Kaltenboeck , Tereza Ruzickova , Veronika Breunhölder , Tarek Zghoul , Philip J Cowen , Catherine J Harmer. No antidepressant-like acute effects of bright light on emotional information processing in healthy volunteers. Psychopharmacology (Berl) . 2021 Nov 6.en
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dc.description.abstractRationale: Bright light treatment (BLT) is an efficacious antidepressant intervention, but its mechanism of action is not well understood. Antidepressant drugs acutely affect how emotional information is processed, pushing the brain to prioritise positive relative to negative input. Whether BLT could have a similar effect is not known to date. Objective: To test whether BLT acutely influences emotional information processing similar to antidepressant drugs, using an established healthy volunteer assay. Methods: Following a double-blind, parallel-group design, 49 healthy volunteers (18-65 years, 26 females) were randomly allocated to 60-min BLT (≥ 10,000 lux) or sham-placebo treatment early in the morning in autumn/winter. Immediately after treatment, emotional information processing was assessed using the Oxford Emotional Test Battery, a validated set of behavioural tasks tapping into emotional information processing in different cognitive domains. Participants also completed questionnaires before and after treatment to assess changes in subjective state. Results: The BLT group did not show significantly more positively biased emotional information processing compared to the placebo group (p > 0.05 for all measures). After adjustment for pre-treatment scores, there were also no significant post-treatment differences between groups in subjective state (p > 0.05 for all measures). Conclusions: BLT did not show immediate effects on emotional information processing in an established healthy volunteer assay. Thus, BLT might exert its clinical effects through a different (cognitive) mechanism than other antidepressant interventions. Future studies should corroborate this finding including clinical populations and more intensive treatment regimes, and control for potential chronobiological effects.en
dc.description.sponsorshipSupported by the NIHRen
dc.subjectAntidepressant Drugsen
dc.titleNo antidepressant-like acute effects of bright light on emotional information processing in healthy volunteersen

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