Show simple item record

dc.contributor.authorExternal author(s) only
dc.date.accessioned2021-08-13T15:11:23Z
dc.date.available2021-08-13T15:11:23Z
dc.date.issued2021-06
dc.identifier.citationMax A. Laansma, Joanna K. Bright, Sarah Al-Bachari, Tim J. Anderson, Tyler Ard, Francesca Assogna, Katherine A. Baquero, Henk W. Berendse, Jamie Blair, Fernando Cendes, John C. Dalrymple-Alford, Rob M.A. de Bie, Ines Debove, Michiel F. Dirkx, Jason Druzgal, Hedley C.A. Emsley,Gäetan Garraux, Rachel P. Guimaraes, Boris A. Gutman, Rick C. Helmich, Johannes C. Klein, Clare E. Mackay, Corey T. McMillan, Tracy R. Melzer, Laura M. Parkes, Fabrizio Piras, Toni L. Pitcher, Kathleen L. Poston, Mario Rango, Letícia F. Ribeiro, Cristiane S. Rocha, Christian Rummel, Lucas S.R. Santos, Reinhold Schmidt, Petra Schwingenschuh, Gianfranco Spalletta, Letizia Squarcina, Odile A. van den Heuvel, Chris Vriend, Jiun-Jie Wang, PhD,33,34 Daniel Weintraub, MD, PhD,35 Roland Wiest, PhD,29 Clarissa L. Yasuda, Neda Jahanshad, Paul M. Thompson, Ysbrand D. van der Werf, and The ENIGMA-Parkinson’s Study.International Multicenter Analysis of Brain Structure Across Clinical Stages of Parkinson’s Disease. Movement Disorders 2021.en
dc.identifier.urihttps://oxfordhealth-nhs.archive.knowledgearc.net/handle/123456789/913
dc.description.abstractABSTRACT: Background: Brain structure abnormalities throughout the course of Parkinson’s disease have yet to be fully elucidated. Objective: Using a multicenter approach and harmonized analysis methods, we aimed to shed light on Parkinson’s disease stage-specific profiles of pathology, as suggested by in vivo neuroimaging. Methods: Individual brain MRI and clinical data from 2357 Parkinson’s disease patients and 1182 healthy controls were collected from 19 sources. We analyzed regional cortical thickness, cortical surface area, and subcortical volume using mixed-effects models. Patients grouped according to Hoehn and Yahr stage were compared with age- and sexmatched controls. Within the patient sample, we investigated associations with Montreal Cognitive Assessment score. Results: Overall, patients showed a thinner cortex in 38 of 68 regions compared with controls (dmax = 0.20, dmin = 0.09). The bilateral putamen (dleft = 0.14,dright = 0.14) and left amygdala (d = 0.13) were smaller in patients, whereas the left thalamus was larger (d = 0.13). Analysis of staging demonstrated an initial presentation of thinner occipital, parietal, and temporal cortices, extending toward rostrally located cortical regions with increased disease severity. From stage 2 and onward, the bilateral putamen and amygdala were consistently smaller with larger differences denoting each increment. Poorer cognition was associated with widespread cortical thinning and lower volumes of core limbic structures. Conclusions: Our findings offer robust and novel imaging signatures that are generally incremental across but in certain regions specific to disease stages. Our findings highlight the importance of adequately powered multicenter collaborations. © 2021 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Societyen
dc.description.sponsorshipSupported by the NIHRen
dc.description.urihttps://DOI: 10.1002/mds.28706en
dc.language.isoenen
dc.subjectParkinson's Diseaseen
dc.titleInternational Multicenter Analysis of Brain Structure Across Clinical Stages of Parkinson’s Diseaseen
dc.typeArticleen


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record