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dc.contributor.authorWaite, Felicity
dc.contributor.authorJohns, Louise
dc.contributor.authorCernis, Emma
dc.contributor.authorMaughan, Daniel L
dc.contributor.authorFreeman, Daniel
dc.date.accessioned2020-12-22T15:46:51Z
dc.date.available2020-12-22T15:46:51Z
dc.date.issued2020-11
dc.identifier.citationFelicity Waite,Thomas Kabir, Louise Johns,Jill Mollison, Apostolos Tsiachristas,Ariane Petit, Emma Černis, Daniel Maughan, and Daniel Freeman. Treating sleep problems in young people at ultra-high-risk of psychosis: study protocol for a single-blind parallel group randomised controlled feasibility trial (SleepWell). BMJ Open. 2020; 10(11): e045235.en
dc.identifier.issn20446055
dc.identifier.urihttps://oxfordhealth-nhs.archive.knowledgearc.net/handle/123456789/676
dc.description.abstractBackground Effective interventions, targeting key contributory causal factors, are needed to prevent the emergence of severe mental health problems in young people. Insomnia is a common clinical issue that is problematic in its own right but that also leads to the development and persistence of psychotic experiences. The implication is that treating sleep problems may prevent the onset of psychosis. We collected initial case series data with 12 young people at ultra-high-risk of psychosis. Post-intervention, there were improvements in sleep, depression and psychotic experiences. Now we test the feasibility of a randomised controlled trial, with a clinical aim to treat sleep problems and hence reduce depression, psychotic experiences, and prevent transition to psychosis. Methods and analysis A randomised controlled feasibility trial will be conducted. Forty patients aged 14 to 25 years who are at ultra-high-risk of psychosis and have sleep disturbance will be recruited from National Health Service (NHS) mental health services. Participants will be randomised to receive either a novel, targeted, youth-focussed sleep intervention in addition to usual care or usual care alone. Assessor-blinded assessments will be conducted at baseline, 3 months (post-intervention) and 9 months (follow-up). The eight-session psychological intervention will target the key mechanisms which disrupt sleep: circadian rhythm irregularities, low sleep pressure, and hyperarousal. To gain an in-depth understanding of participants’ views on the acceptability of the intervention and study procedures, 16 participants (n=10 intervention, n=6 control) will take part in qualitative interviews. Analyses will focus on feasibility outcomes (recruitment, retention, and treatment uptake rates) and provide initial CI estimates of intervention effects. Thematic analysis of the qualitative interviews will assess the acceptability of the intervention and trial procedures.en
dc.description.sponsorshipSupported by the NIHRen
dc.description.urihttps://doi: 10.1136/bmjopen-2020-045235en
dc.language.isoenen
dc.subjectSleepen
dc.subjectPsychosisen
dc.subjectAdolescents and Young Adultsen
dc.titleTreating sleep problems in young people at ultra-high-risk of psychosis: study protocol for a single-blind parallel group randomised controlled feasibility trial (SleepWell).en
dc.typeArticleen


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