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dc.contributor.authorCipriani, Andrea
dc.date.accessioned2020-07-29T16:20:47Z
dc.date.available2020-07-29T16:20:47Z
dc.date.issued2020-07
dc.identifier.citationAstrid Chevance, Prof Philippe Ravaud, Anneka Tomlinson, Catherine Le Berre, Birgit Teufer, Suzanne Touboul, Eiko I Fried, Prof Gerald Gartlehner, Prof Andrea Cipriani, Viet Thi Tra. Identifying outcomes for depression that matter to patients, informal caregivers, and health-care professionals: qualitative content analysis of a large international online survey. Lancet Psychiatry, Volume 7, Issue 8, August 2020, Pages 692-702en
dc.identifier.issn2215-0366
dc.identifier.urihttps://oxfordhealth-nhs.archive.knowledgearc.net/handle/123456789/588
dc.description.abstractMany clinical trials have assessed treatments for depressive disorders and bipolar depression. However, whether, and which, assessed outcome domains really matter to patients, informal caregivers, and health-care professionals remains unclear. Methods:We did an international online survey in French, German, and English. Participants were adult patients with a history of depression, informal caregivers, and health-care professionals, recruited by purposeful sampling. To identify outcome domains, participants answered four open-ended questions about their expectations for depression treatment. We disseminated the survey without restriction via social media, patient and professional associations, and a media campaign. Four researchers independently did qualitative content analyses. We assessed data saturation using mathematical models to ensure the comprehensive identification of outcome domains. Findings:Between April 5, 2018, and Dec 10, 2018, 1912 patients, 464 informal caregivers, and 627 health-care professionals from 52 countries provided 8183 open-ended answers. We identified 80 outcome domains related to symptoms (64 domains), such as mental pain (or psychological or psychic pain, 523 [17%] of 3003 participants) and motivation (384 [13%]), and functioning (16 domains), such as social isolation (541 [18%]). We identified 57 other outcome domains regarding safety of treatment, health care organisation, and social representation, such as stigmatisation (408 [14%]). Interpretation: This study provides a list of outcome domains important to patients, informal caregivers, and health-care professionals. Unfortunately, many of these domains are rarely measured in clinical trials. Results from this study should set the foundation for a core outcome set for depression.en
dc.description.sponsorshipSupported by the NIHRen
dc.description.urihttps://doi.org/10.1016/S2215-0366(20)30191-7en
dc.language.isoenen
dc.subjectDepressive Disordersen
dc.subjectBipolar Disorderen
dc.titleIdentifying outcomes for depression that matter to patients, informal caregivers, and health-care professionals: qualitative content analysis of a large international online surveyen
dc.typeArticleen


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