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Now showing items 21-27 of 27
Altered network stability in progressive supranuclear palsy
(2021-07)
The clinical syndromes of Progressive Supranuclear Palsy (PSP) may be mediated by abnormal temporal dynamics of brain networks, due to the impact of atrophy, synapse loss and neurotransmitter deficits. We tested the ...
Age-related response speed deficits arise from specific impairments in sensory evidence accumulation rate
(2021-11)
Older adults exposed to enriched environments (EE) maintain relatively higher levels of cognitive function, even in the face of compromised markers of brain health. Response speed (RS) is often used as a simple proxy to ...
Accurate expression quantification from nanopore direct RNA sequencing with NanoCount
(2021-11)
Accurately quantifying gene and isoform expression changes is essential to understanding cell functions, differentiation and disease. Sequencing full-length native RNAs using long-read direct RNA sequencing (DRS) has the ...
A macroscopic link between interhemispheric tract myelination and cortico-cortical interactions during action reprogramming
(2021-12)
Myelination has been increasingly implicated in the function and dysfunction of the adult human brain. Although it is known that axon myelination shapes axon physiology in animal models, it is unclear whether a similar ...
Déjà-vu? Neural and behavioural effects of the 5-HT 4 receptor agonist, prucalopride, in a hippocampal-dependent memory task
(2021-10)
Cognitive deficits commonly accompany psychiatric disorders but are often underrecognised, and difficult to treat. The 5-HT4 receptor is a promising potential treatment target for cognitive impairment because in animal ...
Use of online cultural content for mental health and well-being during COVID-19 restrictions: cross-sectional survey
(2021-11)
Aims and method To gain a deeper understanding of the use of online culture and
its potential benefits to mental health and well-being, sociodemographic
characteristics and self-reported data on usage, perceived mental ...
Understanding health anxiety in the COVID-19 pandemic
(2021-11)
The COVID-19 pandemic continues to be one of the greatest public health challenges faced by the UK. Reported rates of psychiatric difficulties have increased and the mechanisms by which the pandemic has affected mental ...