Show simple item record

dc.contributor.authorGodlewska, Beata R
dc.contributor.authorHarmer, Catherine J
dc.identifier.citationBeata R. Godlewska & Catherine J. Harmer . Cognitive neuropsychological theory of antidepressant action: a modern-day approach to depression and its treatment. Psychopharmacology( January 2020)en
dc.descriptionThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.en
dc.description.abstractDepression is a leading cause of disability worldwide and improving its treatment is a core research priority for future programmes. A change in the view of psychological and biological processes, from seeing them as separate to complementing one another, has introduced new perspectives on pathological mechanisms of depression and treatment mode of action. This review presents a theoretical model that incorporated this novel approach, the cognitive neuropsychological hypothesis of antidepressant action. This model proposes that antidepressant treatments decrease the negative bias in the processing of emotionally salient information early in the course of antidepressant treatment, which leads to the clinically significant mood improvement later in treatment. The paper discusses the role of negative affective biases in the development of depression and response to antidepressant treatments. It also discusses whether the model can be applied to other antidepressant interventions and its potential translational value, including treatment choice, prediction of response and drug development.en
dc.description.sponsorshipSupported by the NIHRen
dc.subjectAntidepressant Drugsen
dc.subjectDepressive Disordersen
dc.subjectNegative Affective Biasen
dc.titleCognitive neuropsychological theory of antidepressant action: a modern-day approach to depression and its treatmenten

Files in this item


There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record