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Value of monitoring negative emotional bias in primary care in England for personalised antidepressant treatment: a modelling study
(2019-11)
Depressed patients often focus on negative life events. Effective antidepressant therapy reverses this negative emotional bias (NEB) within 1 week. Clinical therapeutic effect usually requires 4–6 weeks. The value of ...
Predicting Treatment Response to Antidepressant Medication Using Early Changes in Emotional Processing.
(2019-01)
Antidepressants must be taken for weeks before response can be assessed with many patients not responding to the first medication prescribed. This often results in long delays before effective treatment is started. ...
Comparative economic evaluation of quetiapine plus lamotrigine combination vs quetiapine monotherapy (and folic acid vs placebo) in patients with bipolar depression (cequel)
(2018-12)
Although not licensed for acute bipolar depression, lamotrigine has evidence for efficacy in trials and
its use is recommended in guidelines. So far there had been no prospective health economic evaluation of its
use. ...
Mood Homeostasis, Low Mood, and History of Depression in 2 Large Population Samples
(2020-04)
Importance Existing therapeutic options are insufficient to tackle the disease burden of depression, and new treatments are sorely needed. Defining new psychotherapeutic targets is challenging given the paucity of coherent ...
A leaky umbrella has little value: evidence clearly indicates the serotonin system is implicated in depression
(2023-06)
A recent “umbrella” review examined various biomarkers relating to the serotonin system, and concluded there was no consistent evidence implicating serotonin in the pathophysiology of depression. We present reasons for why ...