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Diagnosis Across the Spectrum of Progressive Supranuclear Palsy and Corticobasal Syndrome
(2019-12)
IMPORTANCE: Atypical parkinsonian syndromes (APS), including progressive supranuclear
palsy (PSP), corticobasal syndrome (CBS), and multiple system atrophy (MSA), may be
difficult to distinguish in early stages and are ...
Subthalamic nucleus activity dynamics and limb movement prediction in Parkinson’s disease
(2020-02)
Whilst exaggerated bursts of beta frequency band oscillatory synchronization in the subthalamic nucleus have been associated with motor impairment in Parkinson’s disease, a plausible mechanism linking the two phenomena has ...
Mapping brain structural differences and neuroreceptor correlates in Parkinson's disease visual hallucinations: a mega-analysis
(2021-02)
Parkinson’s psychosis (PDP) describes a spectrum of symptoms that may arise in Parkinson’s disease (PD)
including visual hallucinations (VH). Imaging studies investigating the neural correlates of PDP have been
inconsistent ...
Quantification of allosteric communications in matrix metalloprotease-1 on alpha-synuclein aggregates and substratedependent virtual screening
(2021-01)
Alpha-synuclein (aSyn) has implications in pathological protein aggregations observed in
neurodegenerative disorders, including Parkinson's and Alzheimer's diseases. There are currently
no approved prevention and cure ...
Impulse control disorders in Parkinson disease and RBD
(2019-10)
Objective
To describe the prevalence, natural history, and risk factors for impulse control behaviors
(ICBs) among people with Parkinson disease (PD), those with REM sleep behavior disorder
(RBD), and controls.
Metho ...
Longitudinal Changes in Parkinson’s Disease Symptoms with and Without Rapid Eye Movement Sleep Behavior Disorder: The Oxford Discovery Cohort Study
(2021-08)
Background: Parkinson’s disease (PD) comorbid with rapid eye movement sleep behavior disorder (RBD) may show more severe motor and non motor symptoms, suggesting a distinct PD subtype. Objective: The aim of this study was ...
International Multicenter Analysis of Brain Structure Across Clinical Stages of Parkinson’s Disease
(2021-06)
ABSTRACT: Background: Brain structure abnormalities throughout the course of Parkinson’s disease have
yet to be fully elucidated.
Objective: Using a multicenter approach and harmonized analysis methods, we aimed to shed ...
Predicting motor, cognitive & functional impairment in Parkinson’s
(2019-07)
Objective: We recently demonstrated that 998 features derived from a simple 7-minute smartphone test could distinguish between controls, people with Parkinson’s and people with idiopathic Rapid Eye Movement sleep behavior ...