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Ketamine treatment for depression: qualitative study exploring patient views
(2021-01)
Ketamine is a new and promising treatment for depression but comes with challenges to implement because of its potential for abuse.
Aims
We sought the views of patients to inform policy and practical decisions about ...
Mapping brain structural differences and neuroreceptor correlates in Parkinson's disease visual hallucinations: a mega-analysis
(2021-02)
Parkinson’s psychosis (PDP) describes a spectrum of symptoms that may arise in Parkinson’s disease (PD)
including visual hallucinations (VH). Imaging studies investigating the neural correlates of PDP have been
inconsistent ...
The neurology and neuropsychiatry of COVID-19: a systematic review and meta-analysis of the early literature reveals frequent CNS manifestations and key emerging narratives
(2021-02)
There is accumulating evidence of the neurological and neuropsychiatric features of infection with SARS-CoV-2.
In this systematic review and meta-analysis, we aimed to describe the characteristics of the early literature ...
Blood pressure changes following antihypertensive medication reduction, by drug class and dose chosen for withdrawal: Exploratory analysis of data from the OPTiMISE trial
(2021-02)
Aims: Deprescribing of antihypertensive drugs is recommended for some older patients with
polypharmacy, but there is little evidence to inform which drug (or dose) should be
withdrawn. This study used data from the ...
An Intuitive Risk Communication Tool to Enhance Patient–Provider Partnership in Diabetes Consultation
(2021-02)
Introduction: This technology report introduces an innovative risk communication tool developed to support providers in
communicating diabetes-related risks more intuitively to people with type 2 diabetes mellitus ...
Development and Validation of a Novel Dementia Risk Score in the UK Biobank Cohort
(2021-03)
INTRODUCTION: Current prognostic models of dementia have had limited success in consistently identifying at-risk individuals. We aimed to develop and validate a novel dementia risk score (DRS) using the UK Biobank cohort. ...
Clinical prediction tools to identify patients at highest risk of myeloma in primary care: a retrospective open cohort study
(2021-04)
Background Patients with myeloma experience substantial delays in their diagnosis, which can adversely affect their prognosis.
Aim To generate a clinical prediction rule to identify primary care patients who are at highest ...
An In-vivo 1H-MRS short-echo time technique at 7T: Quantification of metabolites in Chronic Multiple Sclerosis and Neuromyelitis Optica Brain Lesions and Normal Appearing Brain Tissue
(2021-05)
Magnetic Resonance Spectroscopy (MRS) allows for the non-invasive quantification of neurochemicals and has the potential to differentiate between the pathologically distinct diseases, multiple sclerosis (MS) and AQP4Ab-positive ...
Predicting poor outcomes in children aged 1–12 with respiratory tract infections: A systematic review
(2021-04)
Background
Demand for NHS services is high and rising. In children respiratory tract infections (RTI) are the most common reason for consultation with primary care. Understanding which features are associated with good ...
Antimicrobial Peptides SLPI and Beta Defensin-1 in Sputum are Negatively Correlated with FEV1
(2021-05)
Background: Chronic obstructive pulmonary disease (COPD) and asthma have heterogeneous inflammation with inhaled corticosteroids (ICS) as a mainstay of treatment. There is increased prevalence of non-typeable Haemophilus ...