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Defining the relationship between arm and leg blood pressure readings: a systematic review and meta-analysis
(2019-04)
Objectives: To define the relationship between arm and leg blood pressure (BP) to inform the interpretation of leg BP readings in routine clinical practice where arm readings are not available. Methods: Systematic review ...
In Vivo Availability of Cannabinoid 1 Receptor Levels in Patients With First-Episode Psychosis
(2019-07)
Importance: Experimental and epidemiological studies implicate the cannabinoid 1 receptor (CB1R) in the pathophysiology of psychosis. However, whether CB1R levels are altered in the early stages of psychosis and whether ...
Diagnosis Across the Spectrum of Progressive Supranuclear Palsy and Corticobasal Syndrome
(2019-12)
IMPORTANCE: Atypical parkinsonian syndromes (APS), including progressive supranuclear
palsy (PSP), corticobasal syndrome (CBS), and multiple system atrophy (MSA), may be
difficult to distinguish in early stages and are ...
Does cranberry extract reduce antibiotic use for symptoms of acute uncomplicated urinary tract infections (CUTI)? Protocol for a feasibility study
(2019-12)
Consultations in primary care for symptoms of urinary tract infections (UTIs) are common and patients are frequently treated with antibiotics. Given increasing antimicrobial resistance, there has been interest in non-antibiotic ...
Variation in spend on young mental health across Clinical Commissioning Groups in England: a cross-sectional observational study
(2019-08)
Objectives To investigate whether the rate of spend
on child and adolescent mental health is influenced
by demand for other competing services in local
commissioning decisions.
Design Analysis of spend data by Clinical ...
Barriers and facilitators of loaded self-managed exercises and physical activity in people with patellofemoral pain: understanding the feasibility of delivering a multicentred randomised controlled trial, a UK qualitative study
(2019-05)
Objectives: There is an emergent body of evidence supporting exercise therapy and physical activity in the management of musculoskeletal pain. The purpose of this study was to explore potential barriers and facilitators ...
The Functional Consequences of Social Attention for Memory-guided Attention Orienting and Anticipatory Neural Dynamics
(2019-02)
Social attention when viewing natural social (compared to non-social) images has functional consequences on contextual memory in healthy human adults. In addition to attention affecting memory performance, strong evidence ...
Effectiveness of Vitamin D Supplementation in the Management of Multiple Sclerosis: A Systematic Review
(2019-03)
The main objective was to examine the extent of effect vitamin D in Multiple Sclerosis (MS) on pathology and symptoms. A literature search was performed in November 2018 (CRD42018103615).
Eligibility criteria: randomised ...
Potential benefits of a ketogenic diet to improve response and recovery from physical exertion in people with Myalgic encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): A feasibility study
(2019-11)
Background: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) affects approximately 250,000 people in
the UK. The condition varies in severity causing long-term physical and cognitive fatigue which is not ...
Development and implementation of the physiotherapy-led exercise interventions for the treatment of rotator cuff disorders for the ‘Getting it Right: Addressing Shoulder Pain’ (GRASP) trial
(2019-07)
Objectives: The Getting it Right: Addressing Shoulder Pain (GRASP) trial is a large-scale, multicentre, 2 × 2 factorial randomised controlled trial investigating clinical and cost-effectiveness of a progressive exercise ...