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CSF1R inhibitor JNJ-40346527 attenuates microglial proliferation and neurodegeneration in P301S mice
(2019-08)
Neuroinflammation and microglial activation are significant processes in Alzheimer’s disease pathology. Recent genome-wide association studies have highlighted multiple immune-related genes in association with Alzheimer’s ...
Minocycline at 2 Different Dosages vs Placebo for Patients With Mild Alzheimer Disease A Randomized Clinical Trial
(2019-11)
IMPORTANCE There are no disease-modifying treatments for Alzheimer disease (AD), the
most common cause of dementia. Minocycline is anti-inflammatory, protects against the toxic
effects of β-amyloid in vitro and in animal ...