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The genomic basis of mood instability: identification of 46 loci in 363,705 UK Biobank participants, genetic correlation with psychiatric disorders, and association with gene expression and function
(2019)
Genome-wide association studies (GWAS) of psychiatric phenotypes have tended to focus on categorical diagnoses, but to understand the biology of mental illness it may be more useful to study traits which cut across traditional ...
Examination of the neural basis of psychotic-like experiences in adolescence during processing of emotional faces
(2020-03)
Contemporary theories propose that dysregulation of emotional perception is involved in the aetiology of psychosis. 298 healthy adolescents were assessed at age 14- and 19-years using fMRI while performing a facial emotion ...
Unraveling Mechanisms of Patient-Specific NRXN1 Mutations in Neuropsychiatric Diseases Using Human Induced Pluripotent Stem Cells
(2020-03)
Rare heterozygous deletions in the neurexin 1 (NRXN1) gene robustly increase an individual's risk of developing neurological and psychiatric disorders. However, the molecular bases by which different mutations result in ...
Sleep disturbance and psychiatric disorders
(2020-07)
Signs of mental ill health that cut across psychiatric diagnostic categories at high rates are typically viewed as non-specific occurrences, downgraded in importance and disregarded. However, problems not associated with ...
7 Virtual reality (VR) for the treatment of mental health disorders
(2020-07)
Mental health disorders are very common, but far too few people receive the best treatments. Much greater access to the best psychological treatments may be achieved using automated delivery in virtual reality (VR). With ...
Overlap in genetic risk for cross-disorder vulnerability to mental disorders and genetic risk for altered subcortical brain volumes
(2021-01)
Background: There have been considerable recent advances in understanding the genetic architecture of psychiatric disorders as well as the underlying neurocircuitry. However, there is little work on the concordance of
genetic ...
Six-month Neurological and Psychiatric Outcomes in 236,379 Survivors of COVID-19
(2021-01)
Background. Neurological and psychiatric sequelae of COVID-19 have been reported, but
there are limited data on incidence rates and relative risks.
Methods. Using retrospective cohort studies and time-to-event analysis, ...
Bidirectional associations between COVID-19 and psychiatric disorder: retrospective cohort studies of 62 354 COVID-19 cases in the USA
(2020)
Background
Adverse mental health consequences of COVID-19, including anxiety and depression, have been widely predicted but not yet accurately measured. There are a range of physical health risk factors for COVID-19, but ...
The neurology and neuropsychiatry of COVID-19: a systematic review and meta-analysis of the early literature reveals frequent CNS manifestations and key emerging narratives
(2021-02)
There is accumulating evidence of the neurological and neuropsychiatric features of infection with SARS-CoV-2.
In this systematic review and meta-analysis, we aimed to describe the characteristics of the early literature ...
A systematic review and meta-analysis of the Endometriosis and Mental-Health Sequelae; The ELEMI Project
(2021-05)
Background: It is important to evaluate sequalae for complex chronic health conditions such as endometriosis and
mental health disorders. Endometriosis impacts 1 in 10 women. Mental health outcomes can be a primary ...