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Prevalence of Non-Affective Psychoses in Individuals with Autism Spectrum Disorders: A Systematic Review
(2019-08)
Autism spectrum disorders (ASD) and non-affective psychoses such as schizophrenia are commonly acknowledged as discrete entities. Previous research has revealed evidence of high comorbidity between these conditions, but ...
Psychosocial interventions in stimulant use disorders: a systematic review and qualitative synthesis of randomized controlled trials
(2018-09)
Stimulant use disorders are highly prevalent with a large burden of disease. Most clinical guidelines recommend psychosocial interventions, but there are no clear hierarchies or indications. Moreover, these interventions ...
Treatment of Inappropriate Sexual Behavior in Dementia
(2016-08)
Inappropriate sexual behavior (ISB) is a relatively common and potentially disruptive form of behavior in people with dementia. It can cause considerable distress and put placements and people at risk. Yet it is poorly ...
Psychosocial interventions in stimulant use disorders: a focus on women
(2017-07)
Purpose of review: Stimulant use disorders are significant contributors to the global burden of disease, with a growing impact on women. Psychosocial interventions are the gold standard for treating this condition, but ...
The tail wagging the dog: the diagnostic accuracy of first rank symptoms COMMENTARY ON… COCHRANE CORNER
(2019-10)
Outcomes for people with schizophrenia are improved by expedient diagnosis and specific treatment. ICD-11 and DSM-5 have reduced the importance of Schneider's first rank symptoms (FRS) in the diagnosis of schizophrenia; ...
Antidepressants plus benzodiazepines in major depressive disorder: a clinical dilemma with no recent answers from research
(2020-10)
Comorbid anxiety symptoms are common in depression, and adding benzodiazepines to antidepressant treatment may seem a rational clinical solution. Benzodiazepines also have potential to reduce the initial anxiety that may ...
Vortioxetine for depression: the evidence for its current use in the UK: COMMENTARY ON… COCHRANE CORNER
(2018-12-17)
The pharmacological treatment of depression is often hampered by side-effects and unsatisfactory response to treatment. Vortioxetine is one of the newest antidepressants on the market, purportedly with a different mechanism ...
Statins for major depressive disorder: A systematic review and meta-analysis of randomized controlled trials
(2021-03)
The burden of depressive disorder is large and new treatment approaches are required. Repurposing widely available drugs such as statins may be a time- and cost-effective solution. Statins have anti-inflammatory and ...
Ketamine for suicidal ideation: New trial challenges current thinking about ketamine
(2022-02)
Will ketamine be given to eligible patients with suicidal ideation
any time soon? This is hard to say, given the plausible concern that
the widespread use of ketamine might trigger a new opioid style
crisis.10 Whether ...
Statins in depression: a repurposed medical treatment can provide novel insights in mental health
(2022-08)
Depression has a large burden, but the development of new drugs for its treatment has proved difficult. Progresses in neuroscience have highlighted several physiopathological pathways, notably inflammatory and metabolic ...