Browsing Bipolar Disorder by Author "Godlewska, Beata R"
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Changes in brain Glx in depressed bipolar patients treated with lamotrigine: A proton MRS study
Godlewska, Beata R; Masakai, Charles; Bargiotas, Theodoras; Cowen, Philip J (2019-03)Background Lamotrigine is a useful treatment in bipolar depression but requires several weeks of dose titration before its clinical effects can be assessed. Animal experimental studies suggest that lamotrigine lowers ... -
Functional Connectivity between Task-Positive Networks and the Left Precuneus as a Biomarker of Response to Lamotrigine in Bipolar Depression: A Pilot Study
Godlewska, Beata R (2021-06)Treatment of bipolar depression poses a significant clinical challenge. Lamotrigine is one of a few efficacious drugs, however, it needs to be titrated very slowly and response can only be assessed after 10–12 weeks. With ... -
A phase 2a randomised, double-blind, placebo-controlled, parallel-group, add-on clinical trial of ebselen (SPI-1005) as a novel treatment for mania or hypomania.
Sharpley, Ann L; Williams, Clare; Holder, Adele A; Godlewska, Beata R; Macdonald, Orla; Cowen, Philip J (2020-09)Rationale Lithium is an effective prophylactic and anti-manic treatment in bipolar disorder; however, its use is declining through perceived poor tolerance and toxicity. Lithium inhibits inositol monophosphatase (IMPase), ...