Browsing Bipolar Disorder by Author "Godlewska, Beata R"

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Changes in brain Glx in depressed bipolar patients treated with lamotrigine: A proton MRS study

Godlewska, Beata R; Masakai, Charles; Bargiotas, Theodoras; Cowen, Philip J (2019-03)

Background Lamotrigine is a useful treatment in bipolar depression but requires several weeks of dose titration before its clinical effects can be assessed. Animal experimental studies suggest that lamotrigine lowers ...
Functional Connectivity between Task-Positive Networks and the Left Precuneus as a Biomarker of Response to Lamotrigine in Bipolar Depression: A Pilot Study

Godlewska, Beata R (2021-06)

Treatment of bipolar depression poses a significant clinical challenge. Lamotrigine is one of a few efficacious drugs, however, it needs to be titrated very slowly and response can only be assessed after 10–12 weeks. With ...
A phase 2a randomised, double-blind, placebo-controlled, parallel-group, add-on clinical trial of ebselen (SPI-1005) as a novel treatment for mania or hypomania.

Sharpley, Ann L; Williams, Clare; Holder, Adele A; Godlewska, Beata R; Macdonald, Orla; Cowen, Philip J (2020-09)

Rationale Lithium is an effective prophylactic and anti-manic treatment in bipolar disorder; however, its use is declining through perceived poor tolerance and toxicity. Lithium inhibits inositol monophosphatase (IMPase), ...