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Glucocorticoid ultradian rhythmicity differentially regulates mood and resting state networks in the human brain: A randomised controlled clinical trial
(2021-02)
Adrenal glucocorticoid secretion into the systematic circulation is characterised by a complex rhythm, composed of the diurnal variation, formed by changes in pulse amplitude of an underlying ultradian rhythm of short ...
Ketamine treatment for depression: qualitative study exploring patient views
(2021-01)
Ketamine is a new and promising treatment for depression but comes with challenges to implement because of its potential for abuse.
Aims
We sought the views of patients to inform policy and practical decisions about ...
Using the 11-item Version of the RCADS to Identify Anxiety and Depressive Disorders in Adolescents
(2021)
The purpose of this study was to identify items from the Revised Children’s Anxiety and Depression Scale – RCADS-C/P that provided a brief, reliable and valid screen for anxiety and/or depressive disorders in adolescents. ...
A dose-effect network meta-analysis model: an application in antidepressants
(2021-04)
Network meta-analysis (NMA) has been used to answer a range of clinical questions about the preferable intervention for a given condition. Although the effectiveness and safety of pharmacological agents depend on the dose ...
Negative bias in interpretation and facial expression recognition in late life depression: A case control study.
(2021-04)
While cognitive bias in younger adults with depression has been extensively researched, there have been relatively few investigations of the presence of cognitive bias in late life depression (LLD). This exploratory study ...
A continuum hypothesis of psychotomimetic rapid antidepressants
(2021-05)
Ketamine, classical psychedelics and sleep deprivation are associated with rapid effects on depression. Interestingly, these interventions also have common psychotomimetic actions, mirroring aspects of psychosis such as ...
A retrospective examination of care pathways in individuals with treatment-resistant depression
(2021-05)
Individuals with treatment-resistant depression (TRD) experience a high burden of illness. Current guidelines recommend a stepped care approach for treating depression, but the extent to which best-practice care pathways ...
Systematic Review and Meta-analysis: Depressive Symptoms and Risky Behaviors Among Adolescents in Low- and Middle-Income Countries
(2021-05)
Several studies conducted in high-income countries have found an association between depressive symptoms and risky behaviors among adolescents. Evidence from low- and middle-income countries (LMICs), where 90% of the world’s ...
Psychologic Treatment of Depression Compared With Pharmacotherapy and Combined Treatment in Primary Care: A Network Meta-Analysis
(2021-05)
PURPOSE Most patients with depression are treated by general practitioners, and most of those patients prefer psychotherapy over pharmacotherapy. No network meta-analyses have examined the effects of psychotherapy compared ...
Seeing sadness: Comorbid effects of loneliness and depression on emotional face processing
(2021-05)
Background/objective: Loneliness and depression are highly comorbid, and both are associated with social processing deficits. However, there is a paucity of research aimed at differentiating emotional face-processing ...