Browsing Depressive Disorders by Author "De Crescenzo, Franco"
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Development and validation of a meta-learner for combining statistical and machine learning prediction models in individuals with depression
De Crescenzo, Franco; Ostinelli, Edoardo; Tomlinson, Anneka; Cipriani, Andrea (2022-05)The debate of whether machine learning models offer advantages over standard statistical methods when making predictions is ongoing. We discuss the use of a meta-learner model combining both approaches as an alternative. ... -
Natural language processing for structuring clinical text data on depression using UK-CRIS
De Crescenzo, Franco; Harvey, Jade; Cipriani, Andrea (2020-02)Background Utilisation of routinely collected electronic health records from secondary care offers unprecedented possibilities for medical science research but can also present difficulties. One key issue is that medical ... -
Real-world effect of antidepressants for depressive disorder in primary care: protocol of a population-based cohort study
De Crescenzo, Franco; Cipriani, Andrea (2020-06)Introduction Clinical guidelines recommend antidepressants as the first line of treatment for adults with moderate-to-severe depression. Randomised trials provide the best evidence on the comparative effectiveness of ... -
Statins for major depressive disorder: A systematic review and meta-analysis of randomized controlled trials
De Giorgi, Riccardo; De Crescenzo, Franco; Cowen, Philip J; Harmer, Catherine J (2021-03)The burden of depressive disorder is large and new treatment approaches are required. Repurposing widely available drugs such as statins may be a time- and cost-effective solution. Statins have anti-inflammatory and ...