Browsing Depressive Disorders by Author "Browning, Michael"
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Accuracy in recognising happy facial expressions is associated with antidepressant response to a NOP receptor antagonist but not placebo treatment
Browning, Michael; Harmer, Catherine J (2021-10)Background: Clinical trials with putative antidepressants can be difficult to execute as it can take up to 8 weeks before differences emerge between drug and placebo, and long expensive trials often fail. Implementation ... -
Affective bias as a rational response to the statistics of rewards and punishments
Browning, Michael (2017-10)Affective bias, the tendency to differentially prioritise the processing of negative relative to positive events, is commonly observed in clinical and non-clinical populations. However, why such biases develop is not known. ... -
Attentional bias modification is associated with fMRI response toward negative stimuli in individuals with residual depression: a randomized controlled trial
Browning, Michael; Harmer, Catherine J (2019-08)BACKGROUND:Attentional bias modification (ABM) may lead to more adaptive emotion perception and emotion regulation. Understanding the neural basis of these effects may lead to greater precision for the development of future ... -
Characterization of the central nervous system penetrant and selective purine P2X7 receptor antagonist JNJ-54175446 in patients with major depressive disorder
Browning, Michael (2023-07)JNJ-54175446 is a selective purine P2X7 receptor (P2X7R) antagonist that attenuates microglial IL-1β/IL-18 release. In healthy volunteers, JNJ-54175446 suppressed peripheral interleukin (IL)-1β release, and attenuated ... -
A Computational View on the Nature of Reward and Value in Anhedonia
Browning, Michael (2021-08)Anhedonia—a common feature of depression—encompasses a reduction in the subjective experience and anticipation of rewarding events, and a reduction in the motivation to seek out such events. The presence of anhedonia often ... -
A Dissociation of the Acute Effects of Bupropion on Positive Emotional Processing and Reward Processing in Healthy Volunteers
Walsh, Annabel E L; Browning, Michael; Cowen, Philip J; Harmer, Catherine J (2018-10)Background: Previous research indicates that antidepressants can restore the balance between negative and positive emotional processing early in treatment, indicating a role of this effect in later mood improvement. However, ... -
An Experimental Medicine Investigation of the Effects of Subacute Pramipexole Treatment on Emotional Information Processing in Healthy Volunteers
Cowen, Philip J; Harmer, Catherine J; Browning, Michael; Halahakoon, Don Chamith (2021-08)Treatment with the dopamine D2/D3 receptor agonist pramipexole has demonstrated promising clinical effects in patients with depression. However, the mechanisms through which pramipexole might alleviate depressive symptoms ... -
An Experimental Medicine Investigation of the Effects of Subacute Pramipexole Treatment on Emotional Information Processing in Healthy Volunteers
Halahakoon, Don Chamith; Browning, Michael; Cowen, Philip J; Harmer, Catherine J (2021-08)Treatment with the dopamine D2/D3 receptor agonist pramipexole has demonstrated promising clinical effects in patients with depression. However, the mechanisms through which pramipexole might alleviate depressive symptoms ... -
Fifty years on: Serotonin and depression
Cowen, Philip J; Browning, Michael (2023-03)It has been over 50 years since the original serotonin hypothesis was proposed by the British Psychiatrist Alec Coppen. Recently, some authors have questioned the validity of the hypothesis. In this narrative review, we ... -
Inducing Affective Learning Biases with Cognitive Training and Prefrontal tDCS: A Proof-of-Concept Study
Browning, Michael (2020-10)Cognitive models of mood disorders emphasize a causal role of negative affective biases in depression. Computational work suggests that these biases may stem from a belief that negative events have a higher information ... -
A leaky umbrella has little value: evidence clearly indicates the serotonin system is implicated in depression
Browning, Michael; Goodwin, Guy M; McCutcheon, Robert A; Cowen, Philip J (2023-06)A recent “umbrella” review examined various biomarkers relating to the serotonin system, and concluded there was no consistent evidence implicating serotonin in the pathophysiology of depression. We present reasons for why ... -
Negative bias in interpretation and facial expression recognition in late life depression: A case control study.
Baruch, Nina; Behrman, Sophie; Wilkinson, Philip; Browning, Michael (2021-04)While cognitive bias in younger adults with depression has been extensively researched, there have been relatively few investigations of the presence of cognitive bias in late life depression (LLD). This exploratory study ... -
Pramipexole Enhances Reward Learning by Preserving Value Estimates
Halahakoon, Don Chamith; Geddes, John R; Cowen, Philip J; Harmer, Catherine J; Browning, Michael (2022-01)Background: Dopamine D2-like receptor agonists show promise as treatments for depression. They are thought to act by altering how individuals learn from rewarding experiences. However, the nature of these reward learning ... -
Pramipexole for the Treatment of Depression: Efficacy and Mechanisms
Browning, Michael; Halahakoon, Don Chamith (2023-11)Dopaminergic mechanisms are a plausible treatment target for patients with clinical depression but are relatively underexplored in conventional antidepressant medications. There is continuing interest in the potential ... -
Predicting treatment response in depression: the role of anterior cingulate cortex
Godlewska, Beata R; Browning, Michael; Cowen, Philip J; Harmer, Catherine J (2018)Background: Identification of biomarkers predicting therapeutic outcome to antidepressant treatment is one of the most important tasks in current research because it may transform the lengthy process of finding the right ... -
Predicting Treatment Response to Antidepressant Medication Using Early Changes in Emotional Processing.
Browning, Michael; Goodwin, Guy M; Harmer, Catherine J (2019-01)Antidepressants must be taken for weeks before response can be assessed with many patients not responding to the first medication prescribed. This often results in long delays before effective treatment is started. ... -
Pro-dopaminergic pharmacological interventions for anhedonia in depression: protocol for a living systematic review of human and non-human studies
Ostinelli, Edoardo; Browning, Michael; Cipriani, Andrea; Harmer, Catherine J (2023-10)Anhedonia is a key symptom of depression, and it has been suggested as a potential target for future individualised treatments. However, much is unknown about how interventions enhancing dopaminergic pathways may affect ... -
Stimulating human prefrontal cortex increases reward learning
Browning, Michael (2021-01)Work in computational psychiatry suggests that mood disorders may stem from aberrant reinforcement learning processes. Specifically, it is proposed that depressed individuals believe that negative events are more informative ... -
Symptom trajectories in discontinuation trials.
Browning, Michael (2017-02)Many patients with clinical depression, particularly those with recurrent illness, are treated with maintenance antidepressants after an acute-phase response. But how effective is this approach? The effectiveness of ... -
Using Computational Psychiatry to Rule Out the Hidden Causes of Depression
Browning, Michael (2017-08)In an ideal world, our understanding of the causes of psychiatric disorders would progress by testing mechanistic hypotheses in experimental studies, using the results of these studies to identify situations in which the ...