Browsing Depressive Disorders by Author "Cipriani, Andrea"
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Polyunsaturated fatty acids metabolism, purine metabolism and inosine as potential independent diagnostic biomarkers for major depressive disorder in children and adolescents
Cipriani, Andrea (2018-04-20)Major depressive disorder (MDD) in children and adolescents is a recurrent and disabling condition globally but its pathophysiology remains poorly elucidated and there are limited effective treatments available. We performed ... -
Predicting treatment effects in unipolar depression: A meta-review
Tomlinson, Anneka; Cipriani, Andrea (2020-08)There is increasing interest in clinical prediction models in psychiatry, which focus on developing multivariate algorithms to guide personalized diagnostic or management decisions. The main target of these models is the ... -
Pro-dopaminergic pharmacological interventions for anhedonia in depression: protocol for a living systematic review of human and non-human studies
Ostinelli, Edoardo; Browning, Michael; Cipriani, Andrea; Harmer, Catherine J (2023-10)Anhedonia is a key symptom of depression, and it has been suggested as a potential target for future individualised treatments. However, much is unknown about how interventions enhancing dopaminergic pathways may affect ... -
Psychologic Treatment of Depression Compared With Pharmacotherapy and Combined Treatment in Primary Care: A Network Meta-Analysis
Cipriani, Andrea (2021-05)PURPOSE Most patients with depression are treated by general practitioners, and most of those patients prefer psychotherapy over pharmacotherapy. No network meta-analyses have examined the effects of psychotherapy compared ... -
Real-world effect of antidepressants for depressive disorder in primary care: protocol of a population-based cohort study
De Crescenzo, Franco; Cipriani, Andrea (2020-06)Introduction Clinical guidelines recommend antidepressants as the first line of treatment for adults with moderate-to-severe depression. Randomised trials provide the best evidence on the comparative effectiveness of ... -
Selective publication of antidepressant trials and its influence on apparent efficacy: Updated comparisons and meta-analyses of newer versus older trials
Cipriani, Andrea (2022-01)Valid assessment of drug efficacy and safety requires an evidence base free of reporting bias. Using trial reports in Food and Drug Administration (FDA) drug approval packages as a gold standard, we previously found that ... -
Side effect profile and comparative tolerability of 21 antidepressants in the acute treatment of major depression in adults: protocol for a network meta-analysis
New, Emma; Mather, Sarah; Cipriani, Andrea (2019-05)Introduction: We have recently compared all second-generation as well as selected first-generation antidepressants in terms of efficacy and acceptability in the acute treatment of major depression. Here we present a protocol ... -
Sleep deprivation as a treatment for major depressive episodes: A systematic review and meta-analysis
Mitter, Pamina; Geddes, John R; Cipriani, Andrea (2022-05)Sleep deprivation, alone or in combination with pharmacological treatment and as part of a chronotherapy package, is of potential use for people with major depressive episodes, however the evidence base is still conflicting. ... -
Systematic Review and Meta-analysis: Depressive Symptoms and Risky Behaviors Among Adolescents in Low- and Middle-Income Countries
Cipriani, Andrea (2021-05)Several studies conducted in high-income countries have found an association between depressive symptoms and risky behaviors among adolescents. Evidence from low- and middle-income countries (LMICs), where 90% of the world’s ... -
Towards precision in the diagnostic profiling of patients: leveraging symptom dynamics in the assessment of major depressive disorder
Ostinelli, Edoardo; Cipriani, Andrea (2023-08)Major depressive disorder (MDD) is a heterogeneous mental disorder. International guidelines present overall symptom severity as the key dimension for clinical characterisation. However, additional layers of individual ... -
Trends in antidepressant prescriptions in children and young people in England, 1998–2017: protocol of a cohort study using linked primary care and secondary care datasets
Cipriani, Andrea (2019-06)Introduction: Increasing numbers of children and young people (CYP) are receiving prescriptions for antidepressants. This is the protocol of a study aiming to describe the trends and variation in antidepressant prescriptions ... -
Withdrawal, dependence and adverse events of antidepressants: lessons from patients and data
Cipriani, Andrea (2019-10)Editorial.