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Subclinical anxiety and depression are associated with deficits in attentional target facilitation, not distractor inhibition
(2019-06)
Mood and anxiety disorders are associated with deficits in attentional control
involving emotive and non-emotive stimuli. Current theories focus on impaired
attentional inhibition of distracting stimuli in producing these ...
Suicidal ideation and behaviour in patients with persecutory delusions: Prevalence, symptom associations, and psychological correlates
(2019-07)
Background:To determine the prevalence of suicidal ideation and behaviour - and their correlates - in patients with persecutory delusions.
Methods:110 patients with persecutory delusions in the context of non-affective ...
Automated psychological therapy using virtual reality (VR) for patients with persecutory delusions: study protocol for a single-blind parallel-group randomised controlled trial (THRIVE)
(2019-01)
Persecutory delusions are a major psychiatric problem and are associated with a wide range of adverse outcomes. Our theoretical model views these delusions as unfounded threat beliefs which persist due to defence behaviours ...
Potential benefits of a ketogenic diet to improve response and recovery from physical exertion in people with Myalgic encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): A feasibility study
(2019-11)
Background: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) affects approximately 250,000 people in
the UK. The condition varies in severity causing long-term physical and cognitive fatigue which is not ...
Development and implementation of the physiotherapy-led exercise interventions for the treatment of rotator cuff disorders for the ‘Getting it Right: Addressing Shoulder Pain’ (GRASP) trial
(2019-07)
Objectives: The Getting it Right: Addressing Shoulder Pain (GRASP) trial is a large-scale, multicentre, 2 × 2 factorial randomised controlled trial investigating clinical and cost-effectiveness of a progressive exercise ...
Value of monitoring negative emotional bias in primary care in England for personalised antidepressant treatment: a modelling study
(2019-11)
Depressed patients often focus on negative life events. Effective antidepressant therapy reverses this negative emotional bias (NEB) within 1 week. Clinical therapeutic effect usually requires 4–6 weeks. The value of ...
Reproducibility of dietary intakes of macronutrients, specific food groups, and dietary patterns in 211 050 adults in the UK Biobank study
(2019-09)
To detect modest associations of dietary intake with disease risk, observational studies need to be large and control for moderate measurement errors. The
reproducibility of dietary intakes of macronutrients, food groups ...
Clinician barriers and facilitators to heart failure advance care plans: a systematic literature review and qualitative evidence synthesis
(2019-07)
Background:Clinicians hesitate to engage with advance care planning (ACP) in heart failure. We aimed to identify the disease-specific barriers and facilitators for clinicians to engage with ACP.
Methods: We searched ...
Clozapine-induced pericarditis: an ethical dilemma
(2019-06)
Clozapine is an atypical antipsychotic used most frequently in the management of treatment-resistant schizophrenia, where severely unwell patients have failed to respond to standard antipsychotic therapy. Clozapine is ...
Personalise antidepressant treatment for unipolar depression combining individual choices, risks and big data (PETRUSHKA): rationale and protocol
(2019-10)
Introduction: Matching treatment to specific patients is too often a matter of trial and error, while treatment efficacy should be optimised by limiting risks and costs and by incorporating patients’ preferences. Factors ...