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Now showing items 21-30 of 36
A retrospective examination of care pathways in individuals with treatment-resistant depression
(2021-05)
Individuals with treatment-resistant depression (TRD) experience a high burden of illness. Current guidelines recommend a stepped care approach for treating depression, but the extent to which best-practice care pathways ...
Incidence and outcomes of eating disorders during the COVID-19 pandemic
(2021-07)
There are concerns that eating disorders have become commoner during the coronavirus disease 2019 (COVID-19) pandemic. Using the electronic health records of 5.2 million people aged under 30, mostly in the USA, we show ...
Effect of lithium on circadian rhythm in bipolar disorder: A systematic review and meta-analysis
(2021-03)
Circadian rhythm disruption is commonly reported in patients with bipolar disorder. Lithium has been suggested to have effects on the circadian clock, the biological basis of the circadian rhythm. The objective of the ...
The costs of bipolar disorder in the United Kingdom
(2021-09)
Objectives: To estimate the individual cost and population-level economic burden of Bipolar Disorder (BD), and explore the impact of clinical and sociodemographic factors on costs in the United Kingdom.
Methods: Annual ...
Study protocol for a randomised placebo-controlled trial of pramipexole in addition to mood stabilisers for patients with treatment resistant bipolar depression (the PAX-BD study)
(2021-07)
Treatment Resistant Bipolar Depression (TRBD) is a major contributor to the burden of disease associated with Bipolar Disorder (BD). Treatment options for people experiencing bipolar depression are limited to three ...
Clinical- and cost-effectiveness of a technology-supported and solution-focused intervention (DIALOG+) in treatment of patients with chronic depression—study protocol for a multi-site, cluster randomised controlled trial [TACK]
(2022-03)
Many with an acute depressive disorder go on to develop chronic depression, despite ongoing care. There are few specifically designed interventions to treat chronic depression. DIALOG+, a technology-assisted intervention ...
Melatonin In Acute Mania Investigation (MIAMI‐UK). A randomised controlled trial of add‐on melatonin in bipolar disorder
(2020-05)
Objectives
Current options for treating emergent episodes of hypomania and mania in bipolar disorder are limited. Our objective was to compare the effectiveness and safety of add‐on melatonin in hypomania or mania over ...
Plasma glutathione suggests oxidative stress is equally present in early- and late- onset bipolar disorder
(2018-03)
We previously demonstrated oxidative stress in bipolar patients and a
relationship between the age of illness onset and total glutathione, a principal antioxi-
dant. In this study, we sought to replicate these findings ...
Mental health prior to and during the COVID-19 pandemic in individuals with bipolar disorder: Insights from prospective longitudinal data
(2022-03)
Many studies have examined the impact of COVID-19 on the mental health of the public, but few have focused on individuals with existing severe mental illness with longitudinal data before and during the pandemic. Aims: To ...
Association of Schizophrenia Spectrum Disorders and Violence Perpetration in Adults and Adolescents From 15 Countries A Systematic Review and Meta-analysis
(2021-12)
Violence perpetration outcomes in individuals with schizophrenia spectrum disorders contribute to morbidity and mortality at a population level, disrupt care, and lead to stigma.
Objective : To conduct a systematic ...