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Now showing items 191-200 of 207
Molecular and antibody point-of-care tests to support the screening, diagnosis and monitoring of COVID-19
(2020-04)
Moving diagnostic testing for COVID-19 from laboratory settings to the point of care is potentially transformative in the rate and quantity of testing that could be performed. Eleven diagnostic tests that are potentially ...
A single, clinically relevant dose of the GABAB agonist baclofen impairs visuomotor learning
(2020-10)
The GABAB agonist baclofen is taken daily as a treatment for spasticity by millions of stroke, brain injury and multiple sclerosis patients, many of whom are also undergoing motor rehabilitation. However, decreases in GABA ...
Promoting the sexual health of people living with severe mental illness
(2020-08)
Sexual health is an important part of an individual’s overall health profile. However, for people with a severe mental illness (SMI), maintaining optimal sexual health can be a challenge. Mental health nurses have an ...
Inducing Affective Learning Biases with Cognitive Training and Prefrontal tDCS: A Proof-of-Concept Study
(2020-10)
Cognitive models of mood disorders emphasize a causal role of negative affective biases in depression. Computational work suggests that these biases may stem from a belief that negative events have a higher information ...
Covid-19 and mental health: a transformational opportunity to apply an evidence-based approach to clinical practice and research
(2020-04)
The Oxford Precision Psychiatry Lab (https://oxfordhealthbrc.nihr.ac.uk/our-work/oxppl/, @OxfordPPL) collected from senior clinicians in the local Mental Health Trust a list of specific and focused questions about mental ...
Cognitive therapy for post-traumatic stress disorder following critical illness and intensive care unit admission
(2020-04)
Around a quarter of patients treated in intensive care units (ICUs) will develop symptoms of Post-Traumatic Stress Disorder (PTSD). Given the dramatic increase in ICU admissions during the COVID-19 pandemic, post-ICU PTSD ...
Cost and quality-of-life impacts of community treatment orders (CTOs) for patients with psychosis: economic evaluation of the OCTET trial
(2020-07)
Purpose:Current RCT and meta-analyses have not found any effect of community treatment orders (CTOs) on hospital or social outcomes. Assumed positive impacts of CTOs on quality-of-life outcomes and reduced hospital costs ...
Efficacy of digital cognitive behavioral therapy for moderate to severe symptoms of generalized anxiety disorder: A randomized controlled trial
(2020-07)
Cognitive behavioral therapy (CBT) is an efficacious intervention for generalized anxiety disorder (GAD). Digital CBT may provide a scalable means of delivering CBT at a population level. We investigated the efficacy of a ...
Generating comparative evidence on new drugs and devices before approval
(2020-03)
Fewer than half of new drugs have data on their comparative benefits and harms against existing treatment options at the time of regulatory approval in Europe and the USA. Even when active-comparator trials exist, they ...
Effect of glucose and sucrose on cognition in healthy humans: a systematic review and meta-analysis of interventional studies
(2020-06)
Context: Evidence suggests that plasma glucose levels may influence cognitive performance, but this has not been systematically reviewed and quantified. Objective: The aim of this review was to investigate the potential ...