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The knowns and unknowns of SSRI treatment in young people with depression and anxiety: efficacy, predictors, and mechanisms of action
(2021-08)
The use of SSRIs for the treatment of depression and anxiety in young people is increasing. However, the effects of SSRIs in adolescence, a time when there are substantial changes in neural, cognitive, and social functioning, ...
Brain glutamate concentration in men with early psychosis: a magnetic resonance spectroscopy case–control study at 7 T
(2021-06)
Abnormalities in glutamate neurotransmission are linked to psychotic symptoms and cognitive dysfunction in schizophrenia. magnetic resonance spectroscopy (MRS) provides an acceptable means of measuring glutamate in the ...
An Experimental Medicine Investigation of the Effects of Subacute Pramipexole Treatment on Emotional Information Processing in Healthy Volunteers
(2021-08)
Treatment with the dopamine D2/D3 receptor agonist pramipexole has demonstrated
promising clinical effects in patients with depression. However, the mechanisms through which
pramipexole might alleviate depressive symptoms ...
Statins for major depressive disorder: A systematic review and meta-analysis of randomized controlled trials
(2021-03)
The burden of depressive disorder is large and new treatment approaches are required. Repurposing widely available drugs such as statins may be a time- and cost-effective solution. Statins have anti-inflammatory and ...
When Helping is Risky: Behavioral and Neurobiological Mechanisms of Prosocial Decisions Entailing Risk.
(2020-03)
Helping others can entail risks. Doctors that treat infectious patients may risk their own health, intervening in a fight can lead to injury, and organ donations can lead to medical complications. When helping others comes ...
No antidepressant-like acute effects of bright light on emotional information processing in healthy volunteers
(2021-11)
Rationale: Bright light treatment (BLT) is an efficacious antidepressant intervention, but its mechanism of action is not well understood. Antidepressant drugs acutely affect how emotional information is processed, pushing ...
Subchronic treatment with St John’s wort produces a positive shift in emotional processing in healthy volunteers
(2018-11-28)
The neurocognitive model of antidepressant treatment in depression states that antidepressants work by producing relatively immediate positive shifts in emotional processing, which translate into clinical improvement with ...
Predicting treatment response in depression: the role of anterior cingulate cortex
(2018)
Background:
Identification of biomarkers predicting therapeutic outcome to antidepressant treatment is one of the most important tasks in current research because it may transform the lengthy process of finding the right ...
Pramipexole Enhances Reward Learning by Preserving Value Estimates
(2022-01)
Background: Dopamine D2-like receptor agonists show promise as treatments for depression. They are
thought to act by altering how individuals learn from rewarding experiences. However, the nature of these
reward learning ...
Adaptive learning from outcome contingencies in eating-disorder risk groups
(2022-07)
Eating disorders are characterised by altered eating patterns alongside overvaluation of body weight or shape, and have relatively low rates of successful treatment and recovery. Notably, cognitive inflexibility has been ...