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Specialised early intervention for recent-onset psychosis
(2022-03)
Specialised early intervention (SEI) services have seen significant investment and expansion in the UK, aiming to improve long-term outcomes for psychotic disorders. This commentary discusses a recent Cochrane review that ...
Automated virtual reality therapy to treat agoraphobic avoidance and distress in patients with psychosis (gameChange): a multicentre, parallel-group, single-blind, randomised, controlled trial in England with mediation and moderation analyses
(2022-04)
Automated delivery of psychological therapy using immersive technologies such as virtual reality (VR) might greatly increase the availability of effective help for patients. We aimed to evaluate the efficacy of an automated ...
The service user experience of SlowMo therapy: A co-produced thematic analysis of service users' subjective experience
(2022-04)
Objectives: SlowMo is the first blended digital therapy for paranoia, showing significant small-moderate reductions in paranoia in a recent large-scale randomized controlled trial (RCT). This study explored the subjective ...
Psychiatric comorbidity and risk of premature mortality and suicide among those with chronic respiratory diseases, cardiovascular diseases, and diabetes in Sweden: A nationwide matched cohort study of over 1 million patients and their unaffected siblings
(2022-01)
Persons with noncommunicable diseases have elevated rates of premature mortality. The contribution of psychiatric comorbidity to this is uncertain. We aimed to determine the risks of premature mortality and suicide in ...
The psychological journey of weight gain in psychosis
(2022-02)
Rapid weight gain is common with antipsychotic medication. Lost confidence, low mood and medication non-adherence often follow. Yet, the dynamic interactions between the physical and psychological consequences of weight ...
Adapting cognitive behavioural therapy for adolescents with psychosis: insights from the Managing Adolescent first episode in psychosis study (MAPS)
(2022-01)
Background: Onset of psychosis commonly occurs in adolescence, and
long-term prognosis can be poor. There is growing evidence, largely from
adult cohorts, that Cognitive Behavioural Therapy for Psychosis (CBTp)
and ...
SlowMo therapy, a new digital blended therapy for fear of harm from others: An account of therapy personalisation within a targeted intervention
(2022-01)
Objectives: SlowMo therapy is a pioneering blended digital
therapy for paranoia, augmenting face-to-face therapy with
an interactive ‘webapp’ and a mobile app. A recent largescale trial demonstrated small–moderate effects ...
Multisite randomised controlled trial of trauma-focused cognitive behaviour therapy for psychosis to reduce post-traumatic stress symptoms in people with co-morbid post-traumatic stress disorder and psychosis, compared to treatment as usual: study protocol for the STAR (Study of Trauma And Recovery) trial
(2022-05)
People with psychosis have high rates of trauma, with a post-traumatic stress disorder (PTSD) prevalence rate of approximately 15%, which exacerbates psychotic symptoms such as delusions and hallucinations. Pilot studies ...
New drug targets in psychiatry: Neurobiological considerations in the genomics era
(2022-07)
After a period of withdrawal, pharmaceutical companies have begun to reinvest in neuropsychiatric disorders, due to improvements in our understanding of these disorders, stimulated in part by genomic studies. However, ...
A family perspective on parental psychosis: An interpretative phenomenological analysis study
(2022-11)
Objectives: While one third of people with a psychotic
disorder are a parent, there has been little research to date
examining the consequences of this from a whole family
perspective. This study investigates families ...