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Effect of glucose and sucrose on cognition in healthy humans: a systematic review and meta-analysis of interventional studies
(2021-02)
Evidence suggests that plasma glucose levels may influence cognitive performance, but this has not been systematically reviewed and quantified. Objective: The aim of this review was to investigate the potential effects of ...
Individual variation in brain microstructural-cognition relationships in aging
(2021-02)
While all individuals are susceptible to age-related cognitive decline, significant inter- and
intra-individual variability exists. However, the sources of this variation remain poorly understood. Here,
we examined the ...
Negative bias in interpretation and facial expression recognition in late life depression: A case control study.
(2021-04)
While cognitive bias in younger adults with depression has been extensively researched, there have been relatively few investigations of the presence of cognitive bias in late life depression (LLD). This exploratory study ...
Introducing the tablet-based Oxford Cognitive Screen-Plus (OCS-Plus) as an assessment tool for subtle cognitive impairments
(2021-04)
Here, we present the Oxford Cognitive Screen-Plus, a computerised tablet-based screen designed to briefly assess domain-general cognition and provide more fine-grained measures of memory and executive function. The OCS-Plus ...
Quantifying the heterogeneity of cognitive functioning in Alzheimer’s disease to extend the placebo-treatment dichotomy: Latent class analysis of individual-participant data from five pivotal randomized clinical trials of donepezil
(2021-02)
Background. The extent and profiles of heterogeneity in cognitive functioning among participants in clinical trials of antidementia medication are unknown. We aimed to quantify and
identify profiles of heterogeneity of ...
Severity of Post-Stroke Cognitive Impairment Moderates the Relationship Between Cognitive Change and Emotional Distress in the Months Following Stroke
(2021-09)
Depression and anxiety are common psychological consequences of stroke. Here, we
investigated the relationships between cognitive change following stroke, awareness of
cognitive impairments, and mood to further understanding ...
Effect of trazodone on cognitive decline in people with dementia: Cohort study using UK routinely collected data
(2021-09)
Evidence in mouse models has found that the antidepressant trazodone may be protective against neurodegeneration. We therefore aimed to compare cognitive decline of people with dementia taking trazodone with those taking ...
The effect of a one-year vigorous physical activity intervention on fitness, cognitive performance and mental health in young adolescents: the Fit to Study cluster randomised controlled trial
(2021-03)
Background
Physical activity (PA) may positively stimulate the brain, cognition and mental health during adolescence, a period of dynamic neurobiological development. High-intensity interval training (HIIT) or vigorous ...
Delineating between-subject heterogeneity in alpha networks with Spatio-Spectral Eigenmodes
(2021-10)
Between subject variability in the spatial and spectral structure of oscillatory networks can be highly informative but poses a considerable analytic challenge. Here, we describe a data-driven modal decomposition of a ...
Age-related response speed deficits arise from specific impairments in sensory evidence accumulation rate
(2021-11)
Older adults exposed to enriched environments (EE) maintain relatively higher levels of cognitive function, even in the face of compromised markers of brain health. Response speed (RS) is often used as a simple proxy to ...