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Glucocorticoid ultradian rhythmicity differentially regulates mood and resting state networks in the human brain: A randomised controlled clinical trial
(2021-02)
Adrenal glucocorticoid secretion into the systematic circulation is characterised by a complex rhythm, composed of the diurnal variation, formed by changes in pulse amplitude of an underlying ultradian rhythm of short ...
Incidence of neurodegenerative and cerebrovascular diseases associated with antihypertensive drug classes
(2021-01)
Antihypertensive drugs (AHTs) are associated with lowered risks of neurodegenerative diseases and stroke. However, the relative risks associated with different AHT classes are unclear. Using an electronic health record ...
Paranoia in patients attending child and adolescent mental health services
(2021-01)
OBJECTIVE: Paranoia may be particularly prevalent during adolescence, building on the heightened social vulnerabilities at this age. Excessive mistrust may be corrosive for adolescent social relationships, especially in ...
Psychological processes mediating the association between developmental trauma and specific psychotic symptoms in adults: a systematic review and meta-analysis
(2021-02)
Experiencing psychological trauma during childhood and/or adolescence is associated with an increased risk of psychosis in adulthood. However, we lack a clear knowledge of how developmental trauma induces vulnerability to ...
Cognitive therapy for moral injury in post-traumatic stress disorder
(2021-01)
Moral injury is the profound psychological distress which can arise following participating in, or
witnessing, events which transgress an individual’s morals and include harming, betraying, or
failure to help others, or ...
Excessive sleepiness in patients with psychosis: An initial investigation
(2021-01)
Clinical experience indicates that excessive sleepiness and hypersomnia may be a common issue for patients with psychosis. Excessive sleepiness is typically ascribed to the sedating effects of antipsychotic medications but ...
Ketamine treatment for depression: qualitative study exploring patient views
(2021-01)
Ketamine is a new and promising treatment for depression but comes with challenges to implement because of its potential for abuse.
Aims
We sought the views of patients to inform policy and practical decisions about ...
Psychological processes mediating the association between developmental trauma and specific psychotic symptoms in adults: a systematic review and meta-analysis
(2021-01)
Experiencing psychological trauma during childhood and/or adolescence is associated with an increased risk of psychosis in adulthood. However, we lack a clear knowledge of how developmental trauma induces vulnerability to ...
The use of Intensive Interaction within a Positive Behavioural Support framework
(2021-01)
Positive Behavioural Support (PBS) provides an overarching framework for supporting quality‐of‐life improvements for people who use challenging behaviour. Rapport, or the lack of it, is well understood as a setting factor ...
Psychological intervention, antipsychotic medication or a combined treatment for adolescents with a first episode of psychosis: the MAPS feasibility three-arm RCT
(2021-01)
Background: When psychosis emerges in young people there is a risk of poorer outcomes, and access to evidence-based treatments is paramount. The current evidence base is limited. Antipsychotic medications show only a small ...