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Induced pluripotent stem cells in psychiatry: a critical review
(2021-01)
A key challenge in psychiatry research is the development of high-fidelity model systems that can be experimentally manipulated to explore and test pathophysiological mechanisms of illness. In this respect, the emerging ...
Targeting synaptic plasticity in schizophrenia: insights from genomic studies
(2021-08)
Recent genomic findings identify many hundreds of genomic loci that are associated with schizophrenia.
Consistent with data from the pregenomic era, genomic findings implicate synaptic function and plasticity as a tractable ...
Kalirin as a Novel Treatment Target for Cognitive Dysfunction in Schizophrenia
(2021-12)
The cognitive dysfunction experienced by patients with schizophrenia represents a major unmet clinical need. We believe that enhancing synaptic function and plasticity by targeting kalirin may provide a novel means to ...
New drug targets in psychiatry: Neurobiological considerations in the genomics era
(2022-07)
After a period of withdrawal, pharmaceutical companies have begun to reinvest in neuropsychiatric disorders, due to improvements in our understanding of these disorders, stimulated in part by genomic studies. However, ...