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Hemizygous mutations in L1CAM in two unrelated male probands with childhood onset psychosis
(2020-06)
Objective :To identify genes underlying childhood onset psychosis.
Methods :Patients with onset of psychosis at age 13 or younger were identified from clinics across England, and they and their parents were exome sequenced ...
Antipsychotic medication versus psychological intervention versus a combination of both in adolescents with first-episode psychosis (MAPS): a multicentre, three-arm, randomised controlled pilot and feasibility study
(2020-07)
Background
Evidence for the effectiveness of treatments in early-onset psychosis is sparse. Current guidance for the treatment of early-onset psychosis is mostly extrapolated from trials in adult populations. The UK ...
Neural effects of a single dose of fluoxetine on resting-state functional connectivity in adolescent depression
(2020-11)
Fluoxetine is commonly prescribed in adolescent depression, but the neural mechanisms underlying its action remain poorly understood. Here, we used resting-state functional magnetic resonance imaging to investigate the ...
Different Types and Acceptability of Psychotherapies for Acute Anxiety Disorders in Children and Adolescents: A Network Meta-analysis
(2018-10)
Anxiety disorders are common in children and adolescents, and uncertainty
remains regarding the optimal strategy of psychotherapies in this population.
OBJECTIVE: To compare and rank the different types of psychotherapies ...
A single dose of fluoxetine reduces neural limbic responses to anger in depressed adolescents
(2019-01-21)
Depression in adolescence is frequently characterised by symptoms of irritability. Fluoxetine is the antidepressant with
the most favourable benefit:risk ratio profile to treat adolescent depression, but the neural ...
Paranoia in patients attending child and adolescent mental health services
(2021-01)
OBJECTIVE: Paranoia may be particularly prevalent during adolescence, building on the heightened social vulnerabilities at this age. Excessive mistrust may be corrosive for adolescent social relationships, especially in ...
Psychological intervention, antipsychotic medication or a combined treatment for adolescents with a first episode of psychosis: the MAPS feasibility three-arm RCT
(2021-01)
Background: When psychosis emerges in young people there is a risk of poorer outcomes, and access to evidence-based treatments is paramount. The current evidence base is limited. Antipsychotic medications show only a small ...
Acute neural effects of fluoxetine on emotional regulation in depressed adolescents
(2022-05)
Adolescent major depressive disorder (MDD) is associated with disrupted processing of emotional stimuli and difficulties in cognitive reappraisal. Little is known however about how current pharmacotherapies act to modulate ...
Sleep disruption in adolescent inpatients: prevalence, associations with clinical outcomes, and clinician perspectives
(2023-10)
Sleep problems are common for adolescents with psychiatric disorders, and sleep treatment may aid mental health recovery. Inpatient admissions are likely a particularly challenging time for sleep. Despite this little is ...