Browsing by Author "Harrison, Paul J"
Now showing items 1-20 of 35
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Absent sleep EEG spindle activity in GluA1 (Gria1) knockout mice: relevance to neuropsychiatric disorders
Harrison, Paul J (2018-08)Sleep EEG spindles have been implicated in attention, sensory processing, synaptic plasticity and memory consolidation. In humans, deficits in sleep spindles have been reported in a wide range of neurological and psychiatric ... -
Accurate expression quantification from nanopore direct RNA sequencing with NanoCount
Harrison, Paul J (2021-11)Accurately quantifying gene and isoform expression changes is essential to understanding cell functions, differentiation and disease. Sequencing full-length native RNAs using long-read direct RNA sequencing (DRS) has the ... -
Acute blood biomarker profiles predict cognitive deficits 6 and 12 months after COVID-19 hospitalization
Taquet, Maxime; Geddes, John R; Harrison, Paul J (2023-08)Post-COVID cognitive deficits, including 'brain fog', are clinically complex, with both objective and subjective components. They are common and debilitating, and can affect the ability to work, yet their biological ... -
Bidirectional associations between COVID-19 and psychiatric disorder: retrospective cohort studies of 62 354 COVID-19 cases in the USA
Taquet, Maxime; Geddes, John R; Harrison, Paul J (2020)Background Adverse mental health consequences of COVID-19, including anxiety and depression, have been widely predicted but not yet accurately measured. There are a range of physical health risk factors for COVID-19, but ... -
CACNA1C (CaV1.2) and other L-type calcium channels in the pathophysiology and treatment of psychiatric disorders: Advances from functional genomics and pharmacoepidemiology
Harrison, Paul J; Colbourne, Lucy; Mould, Arne; Tunbridge, Elizabeth (2022-09)A role for voltage-gated calcium channels (VGCCs) in psychiatric disorders has long been postulated as part of a broader involvement of intracellular calcium signalling. However, the data were inconclusive and hard to ... -
Catechol-O-methyltransferase activity does not influence emotional processing in men
Martens, M A G; Scaife, Jessica; Harmer, Catherine J; Harrison, Paul J; Tunbridge, Elizabeth (2022-04)Background: Catechol-O-methyltransferase (COMT) regulates cortical dopaminergic transmission and prefrontal-dependent cognitive function. However, its role in other cognitive processes, including emotional processing, is ... -
Cerebral venous thrombosis: a retrospective cohort study of 513,284 confirmed COVID-19 cases and a comparison with 489,871 people receiving a COVID-19 mRNA vaccine
Taquet, Maxime; Geddes, John R; Harrison, Paul J (2021-04)Objectives To estimate the absolute risk of cerebral venous thrombosis (CVT) and portal vein thrombosis (PVT) in the two weeks following a diagnosis of COVID-19, and to assess the relative risks (RR) compared to influenza ... -
Characterizing Affective Variability in Bipolar Disorder and Borderline Personality Disorder, and the Effects of Lithium, Using a Generative Model of Affect
Saunders, Kate E.A.; Harmer, Catherine J; Harrison, Paul J; Goodwin, Guy M; Geddes, John R; Browning, Michael (2022-02)The affective variability of Bipolar Disorder (BD) is thought to qualitatively differ from that of Borderline Personality Disorder (BPD), with changes in affect persisting for longer in BD. However, quantitative studies ... -
Cognitive Behavioural Therapy for Nightmares for Patients with Persecutory Delusions (Nites): An Assessor-Blind, Pilot Randomized Controlled Trial
Sheaves, Bryony; Waite, Felicity; Harrison, Paul J; Freeman, Daniel (2019-05)Objective:Nightmares are relatively common in patients experiencing psychosis but rarely assessed or treated. Nightmares may maintain persecutory delusions by portraying fears in sensory-rich detail. We tested the potential ... -
Cognitive Remediation in Bipolar (CRiB2): study protocol for a randomised controlled trial assessing efficacy and mechanisms of cognitive remediation therapy compared to treatment as usual
Harrison, Paul J; Harmer, Catherine J; Browning, Michael (2023-11)A substantial proportion of people with bipolar disorder (BD) experience persistent cognitive difficulties associated with impairments in psychosocial functioning and a poorer disorder course. Emerging evidence suggests ... -
Depression and anxiety disorders during the COVID-19 pandemic: knowns and unknowns
Taquet, Maxime; Harrison, Paul J (2021-10)The COVID-19 pandemic has taken a toll on people's mental health. Yet, the global extent of this impact remains largely unknown. By leveraging the best available data from surveys around the world with measurements of ... -
Dopaminergic modulation of regional cerebral blood flow: An arterial spin labelling study of genetic and pharmacological manipulation of COMT activity
Martens, M A G; Philippini, N; Harrison, Paul J; Tunbridge, Elizabeth; Mackay, Clare (2021-07)Dopamine has direct and complex vasoactive effects on cerebral circulation. Catechol-O-methyltransferase (COMT) regulates cortical dopamine, and its activity can be influenced both genetically and pharmacologically. COMT ... -
Ethical Issues in Consent for the Re-use of Data in Health Data Platforms
Harrison, Paul J (2020-12)Data platforms represent a new paradigm for carrying out health research. In the platform model, datasets are pooled for remote access and analysis, so novel insights for developing better stratified and / or personalised ... -
Exposure to phenytoin associates with a lower risk of post-COVID cognitive deficits: a cohort study
Taquet, Maxime; Harrison, Paul J (2022-08)Post-COVID cognitive deficits (often referred to as ‘brain fog’) are common and have large impacts on patients’ level of functioning. No specific intervention exists to mitigate this burden. This study tested the hypothesis, ... -
Genetics of self-reported risk-taking behaviour, trans-ethnic consistency and relevance to brain gene expression
Tunbridge, Elizabeth; Harrison, Paul J (2018)Risk-taking behaviour is an important component of several psychiatric disorders, including attention-deficit hyperactivity disorder, schizophrenia and bipolar disorder. Previously, two genetic loci have been associated ... -
The genomic basis of mood instability: identification of 46 loci in 363,705 UK Biobank participants, genetic correlation with psychiatric disorders, and association with gene expression and function
Tunbridge, Elizabeth; Harrison, Paul J (2019)Genome-wide association studies (GWAS) of psychiatric phenotypes have tended to focus on categorical diagnoses, but to understand the biology of mental illness it may be more useful to study traits which cut across traditional ... -
GRIN2A (NR2A): a gene contributing to glutamatergic involvement in schizophrenia
Harrison, Paul J (2023-09)Involvement of the glutamate system, particularly N-methyl-D-aspartate (NMDA) receptor hypofunction, has long been postulated to be part of the pathophysiology of schizophrenia. An important development is provided by ... -
Incidence and outcomes of eating disorders during the COVID-19 pandemic
Taquet, Maxime; Harrison, Paul J; Geddes, John R (2021-07)There are concerns that eating disorders have become commoner during the coronavirus disease 2019 (COVID-19) pandemic. Using the electronic health records of 5.2 million people aged under 30, mostly in the USA, we show ... -
Incidence of Epilepsy and Seizures Over the First 6 Months After a COVID-19 Diagnosis
Taquet, Maxime; Harrison, Paul J (2022-11)Background and Objectives The relationship between COVID-19 and epilepsy is uncertain. We studied the potential association between COVID-19 and seizures or epilepsy in the 6 months after infection. Methods We applied ... -
Incidence of neurodegenerative and cerebrovascular diseases associated with antihypertensive drug classes
Harrison, Paul J; Colbourne, Lucy (2021-01)Antihypertensive drugs (AHTs) are associated with lowered risks of neurodegenerative diseases and stroke. However, the relative risks associated with different AHT classes are unclear. Using an electronic health record ...