• Login
    View Item 
    •   ORKA Home
    • Settings
    • Population Health
    • View Item
    •   ORKA Home
    • Settings
    • Population Health
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Exposure to phenytoin associates with a lower risk of post-COVID cognitive deficits: a cohort study

    Thumbnail
    View/Open
    Main article (777.3Kb)
    Date
    2022-08
    Author
    Taquet, Maxime
    Harrison, Paul J
    Metadata
    Show full item record
    Citation
    Maxime Taquet and Paul J. Harrison. Exposure to phenytoin associates with a lower risk of post-COVID cognitive deficits: a cohort study. BRAIN COMMUNICATIONS 2022; 4(4): fcac2062022
    Abstract
    Post-COVID cognitive deficits (often referred to as ‘brain fog’) are common and have large impacts on patients’ level of functioning. No specific intervention exists to mitigate this burden. This study tested the hypothesis, inspired by recent experimental research, that post-COVID cognitive deficits can be prevented by inhibiting receptor-interacting protein kinase. Using electronic health record data, we compared the cognitive outcomes of propensity8 score-matched cohorts of patients with epilepsy taking phenytoin (a commonly used receptor-interacting protein kinase inhibitor) versus valproate or levetiracetam at the time of COVID-19 diagnosis. Patients taking phenytoin at the time of COVID-19 were at a significantly lower risk of cognitive deficits in the 6 months after COVID-19 infection than a matched cohort of patients receiving levetiracetam (hazard ratio 0.78, 95% confidence interval 0.63–0.97, P=0.024) or valproate (hazard ratio 0.73, 95% confidence interval 0.58–0.93, P=0.011). In secondary analyses, results were robust when controlling for subtype of epilepsy, and showed specificity to cognitive deficits in that similar associations were not seen with other ‘long-COVID’ outcomes such as persistent breathlessness or pain. These findings provide pharmacoepidemiological support for the hypothesis that receptor-interacting protein kinase signaling is involved in post-COVID cognitive deficits. These results should prompt empirical investigations of receptor-interacting protein kinase inhibitors in the prevention of post-COVID cognitive deficits.
    Description
    Open Access
    URI
    https://oxfordhealth-nhs.archive.knowledgearc.net/handle/123456789/1132
    Published online at:
    https://doi.org/10.1093%2Fbraincomms%2Ffcac206
    Collections
    • Population Health [25]

    Oxford Health copyright © 2019
    Contact Us | Send Feedback | JSPUI
    Powered by KnowledgeArc
     

     

    Browse

    All of ORKACommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsContributor DisciplineThis CollectionBy Issue DateAuthorsTitlesSubjectsContributor Discipline

    My Account

    Login

    Researcher Profiles

    Researchers

    Oxford Health copyright © 2019
    Contact Us | Send Feedback | JSPUI
    Powered by KnowledgeArc