Browsing by Author "Harrison, Paul J"
Now showing items 21-35 of 35
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Incidence of Parkinson’s disease, dementia, cerebrovascular disease and stroke in bipolar disorder compared to other psychiatric disorders: An electronic health records network study of 66 million people
Harrison, Paul J (2020-10)Bipolar disorder has been associated with an increased risk for neurodegenerative diseases, but uncertainties remain. The risk relative to other psychiatric disorders is not established. Methods We used a federated ... -
Incidence, co-occurrence, and evolution of long-COVID features: A 6-month retrospective cohort study of 273,618 survivors of COVID-19
Taquet, Maxime; Geddes, John R; Harrison, Paul J (2021-09)Long-COVID refers to a variety of symptoms affecting different organs reported by people following Coronavirus Disease 2019 (COVID-19) infection. To date, there have been no robust estimates of the incidence and co-occurrence ... -
Induced pluripotent stem cells in psychiatry: a critical review
De Los Angeles, Alejandro; Hall, Nicola A; Harrison, Paul J; Tunbridge, Elizabeth (2021-01)A key challenge in psychiatry research is the development of high-fidelity model systems that can be experimentally manipulated to explore and test pathophysiological mechanisms of illness. In this respect, the emerging ... -
Neurological and psychiatric risk trajectories after SARS-CoV-2 infection: an analysis of 2-year retrospective cohort studies including 1 284 437 patients
Taquet, Maxime; Harrison, Paul J (2022-08)COVID-19 is associated with increased risks of neurological and psychiatric sequelae in the weeks and months thereafter. How long these risks remain, whether they affect children and adults similarly, and whether SARS-CoV-2 ... -
New drug targets in psychiatry: Neurobiological considerations in the genomics era
Harrison, Paul J; Mould, Arne; Tunbridge, Elizabeth (2022-07)After a period of withdrawal, pharmaceutical companies have begun to reinvest in neuropsychiatric disorders, due to improvements in our understanding of these disorders, stimulated in part by genomic studies. However, ... -
Onset and recurrence of psychiatric disorders associated with anti-hypertensive drug classes
Colbourne, Lucy; Harrison, Paul J (2021-05)The major anti-hypertensive (AHT) drug classes have been associated with differential risks of psychiatric disorders. However, existing data are limited largely to depression, and confounding variables have not always been ... -
Patient fibroblast circadian rhythms predict lithium sensitivity in bipolar disorder
Cipriani, Andrea; Attenburrow, Mary Jane; Harrison, Paul J; Goodwin, Guy M (2020-05)Bipolar disorder is a chronic neuropsychiatric condition associated with mood instability, where patients present significant sleep and circadian rhythm abnormalities. Currently, the pathophysiology of bipolar disorder ... -
Paul Harrison—investigating the psychiatric sequelae of COVID-19
Harrison, Paul J (2022-04)Paul Harrison describes his academic career as being low profile until several large studies on the psychiatric effects of COVID-19, including those linked to so called long-COVID, thrust him and his team into the limelight. ... -
The psychopathology of NMDAR-antibody encephalitis in adults: a systematic review and phenotypic analysis of individual patient data
Lennox, Belinda; Harrison, Paul J (2019-03)Early immunotherapy administration improves outcomes in patients with N-methyl-D-aspartate receptor (NMDAR)-antibody encephalitis. As most patients with NMDAR-antibody encephalitis present to psychiatrists, the psychopathology ... -
Six-month Neurological and Psychiatric Outcomes in 236,379 Survivors of COVID-19
Taquet, Maxime; Geddes, John R; Harrison, Paul J (2021-01)Background. Neurological and psychiatric sequelae of COVID-19 have been reported, but there are limited data on incidence rates and relative risks. Methods. Using retrospective cohort studies and time-to-event analysis, ... -
Sleep disturbance and psychiatric disorders
Freeman, Daniel; Sheaves, Bryony; Waite, Felicity; Harrison, Paul J (2020-07)Signs of mental ill health that cut across psychiatric diagnostic categories at high rates are typically viewed as non-specific occurrences, downgraded in importance and disregarded. However, problems not associated with ... -
A Structural Brain Network of Genetic Vulnerability to Psychiatric Illness
Harrison, Paul J (2020-05)Psychiatry is undergoing a paradigm shift from the acceptance of distinct diagnoses to a representation of psychiatric illness that crosses diagnostic boundaries. How this transition is supported by a shared neurobiology ... -
Voltage-gated calcium channel blockers for psychiatric disorders: genomic reappraisal
Harrison, Paul J; Tunbridge, Elizabeth (2019-06)We reappraise the psychiatric potential of calcium channel blockers (CCBs). First, voltage-gated calcium channels are risk genes for several disorders. Second, use of CCBs is associated with altered psychiatric risks and ... -
Which Dopamine Polymorphisms are Functional? Systematic Review and Meta-Analysis of COMT, DAT, DBH, DDC, DRD1-5, MAOA, MAOB, TH, VMAT1 and VMAT2
Tunbridge, Elizabeth; Cipriani, Andrea; Harrison, Paul J (2019-05)BACKGROUND: Many polymorphisms in dopamine genes are reported to affect cognitive, imaging or clinical phenotypes. It is often inferred or assumed that such associations are causal, mediated by a direct effect of the ... -
Why is COVID-19 associated with mental illness?
Taquet, Maxime; Harrison, Paul J (2021-08)The COVID-19 pandemic has taken a toll on people’s mental health. Besides the indirect impact of the pandemic, a diagnosis of COVID 19 is itself associated with a greater risk of subsequent mental illness. Conversely, ...