Browsing by Author "Cipriani, Andrea"
Now showing items 41-60 of 104
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Explainable artificial intelligence for mental health through transparency and interpretability for understandability
Smith, Katharine A; Cipriani, Andrea (2023-01)The literature on artificial intelligence (AI) or machine learning (ML) in mental health and psychiatry lacks consensus on what “explainability” means. In the more general XAI (eXplainable AI) literature, there has been ... -
Generating comparative evidence on new drugs and devices before approval
Cipriani, Andrea (2020-03)Fewer than half of new drugs have data on their comparative benefits and harms against existing treatment options at the time of regulatory approval in Europe and the USA. Even when active-comparator trials exist, they ... -
How Efficacious Are Antipsychotic Drugs for Schizophrenia? An Interpretation Based on 13 Effect Size Indices
Cipriani, Andrea (2021-08)Background The magnitude of the superiority of antipsychotics over placebo is debated. One reason is that the effect-size index which is usually used in meta-analyses is in standard deviation units. Many other indices, ... -
How pharmacist prescribers can help meet the mental health consequences of COVID-19
Macdonald, Orla; Smith, Katharine A; Marven, Michael; Broughton, Nick; Geddes, John R; Cipriani, Andrea (2020-11)We suggest that Mental Health Trusts should urgently develop prescribing roles for specialist mental health pharmacists, which are integrated within mental health teams. In these roles, prescribing pharmacists can ... -
Identifying outcomes for depression that matter to patients, informal caregivers, and health-care professionals: qualitative content analysis of a large international online survey
Cipriani, Andrea (2020-07)Many clinical trials have assessed treatments for depressive disorders and bipolar depression. However, whether, and which, assessed outcome domains really matter to patients, informal caregivers, and health-care professionals ... -
Impact of placebo arms on outcomes in antidepressant trials: systematic review and meta-regression analysis
Cipriani, Andrea (2018-06)There is debate in the literature as to whether inclusion of a placebo arm may alter characteristics of antidepressant trials. However, previous research has focused on response rates of various antidepressants on average ... -
The Impact of the COVID-19 Pandemic and Associated Control Measures on the Mental Health of the General Population:A Systematic Review and Dose–Response Meta-analysis
Fazel, Seena; Cipriani, Andrea (2022-11)To what extent the COVID-19 pandemic and its containment measures influenced mental health in the general population is still unclear. Purpose: To assess the trajectory of mental health symptoms during the first year ... -
Impact of the COVID-19 Pandemic on the Global Delivery of Mental Health Services and Telemental Health: Systematic Review
Macdonald, Orla; Reid, Katherine; Bale, Robert; Hawton, Keith; Cipriani, Andrea (2022-08)The COVID-19 pandemic required mental health services around the world to adapt quickly to the new restrictions and regulations put in place to reduce the risk of transmission. As face-to-face contact became difficult, ... -
Implementation of a Web-Based Resilience Enhancement Training for Nurses: Pilot Randomized Controlled Trial
Henshall, Catherine; Hart, Liam; Cipriani, Andrea (2023-02)Global workforce challenges faced by health care providers are linked to low levels of job satisfaction, recruitment, retention, and well-being, with detrimental impacts on patient care outcomes. Resilience-building programs ... -
Implementing a digital clinical decision support tool for side effects of antipsychotics: a focus group study
Henshall, Catherine; Cipriani, Andrea; Macdonald, Orla (2019-04-15)In medicine, algorithms can inform treatment decisions by combining the most up-to-date evidence about side effect profiles of medications, which are comparable in efficacy. Their use provides opportunities for improved ... -
Important adverse events to be evaluated in antidepressant trials and meta-analyses in depression: a large international preference study including patients and healthcare professionals
Tomlinson, Anneka; Henshall, Catherine; Cipriani, Andrea (2022-07)Background: Non-serious adverse events (NSAEs) should be captured and reported because they can have a significant negative impact on patients and treatment adherence. However, the reporting of NSAEs in randomised controlled ... -
Informing National Health Service patients about participation in clinical research: A comparison of opt-in and opt-out approaches across the United Kingdom
Cipriani, Andrea; Henshall, Catherine; Potts, Jennifer; Hancock, Mark; Underwood, Mark; Broughton, Nick; Ede, Roger; Kernot, Catherine; O'Neill, Lorcan; Geddes, John R (2020-11)Objective: Recruitment to clinical research in the National Health Service remains challenging. One barrier is accessing patients to discuss research participation. Two general approaches are used in the United Kingdom ... -
Initial treatment choices to achieve sustained response in major depression: a systematic review and network meta-analysis
Cipriani, Andrea; Ostinelli, Edoardo (2021-10)Major depression is often a relapsing disorder. It is therefore important to start its treatment with therapies that maximize the chance of not only getting the patients well but also keeping them well. We examined the ... -
Is placebo response in antidepressant trials rising or not? A reanalysis of datasets to conclude this long-lasting controversy
Cipriani, Andrea; Atkinson, Lauren Z (2018-01)It had long been believed that placebo response rates in antidepressant trials have been increasing and that they were responsible for rising numbers of so-called failed antidepressant trials. Two recent systematic reviews ... -
It’s What We Do: Experiences of UK Nurses Working during the COVID-19 Pandemic: Impact on Practice, Identity and Resilience
Henshall, Catherine; Cipriani, Andrea (2022-09)The COVID-19 pandemic increased pressure on a nursing workforce already facing high levels of stress, burnout, and fatigue in the United Kingdom (UK) and internationally. The contribution of nurses to keeping the public ... -
Ketamine for suicidal ideation in adults with psychiatric disorders: A systematic review and meta-analysis of treatment trials
Potts, Jennifer; Cipriani, Andrea; Hawton, Keith (2019-07)Ketamine may reduce suicidal ideation in treatment-resistant depression. But it is not known how quickly this occurs and how long it persists. We undertook a systematic review and meta-analysis to determine the short and ... -
The Kilim plot: A tool for visualizing network meta‐analysis results for multiple outcomes
Cipriani, Andrea; Tomlinson, Anneka (2020-06)Network meta‐analysis (NMA) can be used to compare multiple competing treatments for the same disease. In practice, usually a range of outcomes is of interest. As the number of outcomes increases, summarizing results from ... -
Linking the Mini-Mental State Examination, the Alzheimer’s Disease Assessment Scale–Cognitive Subscale and the Severe Impairment Battery: evidence from individual participant data from five randomised clinical trials of donepezil
Cipriani, Andrea (2020-10)Background The Mini-Mental State Examination (MMSE), the Alzheimer’s Disease Assessment Scale–Cognitive Subscale (ADAS-Cog) and the Severe Impairment Battery (SIB) are widely used rating scales to assess cognition in ... -
Living network meta-analysis compared with pairwise meta-analysis in comparative effectiveness research: empirical study
Cipriani, Andrea (2018-02-28)Objective:To examine whether the continuous updating of networks of prospectively planned randomised controlled trials (RCTs) (“living” network meta-analysis) provides strong evidence against the null hypothesis in comparative ... -
Magnitude and variability of structural brain abnormalities in neuropsychiatric disease: protocol for a network meta-analysis of MRI studies
Cipriani, Andrea (2021-04)Introduction Structural MRI is the most frequently used method to investigate brain volume alterations in neuropsychiatric disease. Previous meta-analyses have typically focused on a single diagnosis, thereby precluding ...