Browsing by Author "Cipriani, Andrea"
Now showing items 21-40 of 104
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COVID-19 and substance use disorders: a review of international guidelines for frontline healthcare workers of addiction services
Ostinelli, Edoardo; Smith, Katharine A; Zangani, Caroline; Macdonald, Orla; Cipriani, Andrea (2022-03)People with substance use disorders may be at a greater risk of contracting COVID-19 infection and developing medical complications. Several institutional and governmental health agencies across the world developed ad hoc ... -
COVID-19 vaccines, hesitancy and mental health
Smith, Katharine A; Freeman, Daniel; Cipriani, Andrea (2021-04)‘None of us will be safe until everyone is safe. Global access to coronavirus vaccines, tests and treatments for everyone who needs them, anywhere, is the only way out’. This statement by Dr Tedros Adhanom Ghebreyesus, ... -
COVID-19, mental health and ethnic minorities
Smith, Katharine A; Cipriani, Andrea (2020-07)There is little formal guidance for the busy clinician in balancing different risks for individual mental health patients and treating appropriately. To fill this gap, we propose three core actions that may help: 1. ... -
Development and validation of a meta-learner for combining statistical and machine learning prediction models in individuals with depression
De Crescenzo, Franco; Ostinelli, Edoardo; Tomlinson, Anneka; Cipriani, Andrea (2022-05)The debate of whether machine learning models offer advantages over standard statistical methods when making predictions is ongoing. We discuss the use of a meta-learner model combining both approaches as an alternative. ... -
Development and validation of a prediction model for the probability of responding to placebo in antidepressant trials: a pooled analysis of individual patient data
Cipriani, Andrea (2019-02)Background: Identifying potential placebo responders among apparent drug responders is critical to dissect drug-specific and nonspecific effects in depression. Objective: This project aimed to develop and test a prediction ... -
Different Types and Acceptability of Psychotherapies for Acute Anxiety Disorders in Children and Adolescents: A Network Meta-analysis
Cipriani, Andrea; James, Anthony (2018-10)Anxiety disorders are common in children and adolescents, and uncertainty remains regarding the optimal strategy of psychotherapies in this population. OBJECTIVE: To compare and rank the different types of psychotherapies ... -
A dose-effect network meta-analysis model: an application in antidepressants
Cipriani, Andrea (2021-04)Network meta-analysis (NMA) has been used to answer a range of clinical questions about the preferable intervention for a given condition. Although the effectiveness and safety of pharmacological agents depend on the dose ... -
Dose–effect meta-analysis for psychopharmacological interventions using randomised data
Cipriani, Andrea (2022-01)Objective The current practice in meta-analysis of the effects of psychopharmacological interventions ignors the administered dose or restricts the analysis in a dose range. This may introduce unnecessary uncertainty and ... -
A dose–effect network meta-analysis model with application in antidepressants using restricted cubic splines
Cipriani, Andrea (2022-02)Network meta-analysis has been used to answer a range of clinical questions about the preferred intervention for a given condition. Although the effectiveness and safety of pharmacological agents depend on the dose ... -
Early- and subsequent- response of cognitive functioning in Alzheimer's disease: Individual-participant data from five pivotal randomized clinical trials of donepezil
Cipriani, Andrea (2022-02)The association between early improvement and subsequent change in cognition is unexamined in antidementia clinical trials. We aimed to examine the consequences of early-response to antidementia medication in Alzheimer's ... -
Effect of lithium on circadian rhythm in bipolar disorder: A systematic review and meta-analysis
Saunders, Kate E.A.; Cipriani, Andrea; Geddes, John R (2021-03)Circadian rhythm disruption is commonly reported in patients with bipolar disorder. Lithium has been suggested to have effects on the circadian clock, the biological basis of the circadian rhythm. The objective of the ... -
Effectiveness and Acceptability of Cognitive Behavior Therapy Delivery Formats in Adults With Depression A Network Meta-analysis
Cipriani, Andrea (2019-04)Importance Cognitive behavior therapy (CBT) has been shown to be effective in the treatment of acute depression. However, whether CBT can be effectively delivered in individual, group, telephone-administered, guided ... -
The effects of incretin‐based therapies on β‐cell function and insulin resistance in type 2 diabetes: A systematic review and network meta‐analysis combining 360 trials
Cipriani, Andrea (2018-12-09)Aim To evaluate the comparative effects of incretin‐based therapies, including glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) and dipeptidyl peptidase‐4 inhibitors (DPP‐4Is), on β‐cell function and insulin resistance ... -
Efficacy and Acceptability of Interventions for Attenuated Positive Psychotic Symptoms in Individuals at Clinical High Risk of Psychosis: A Network Meta-Analysis
Cipriani, Andrea (2018-06-12)Background: Attenuated positive psychotic symptoms represent the defining features of the clinical high-risk for psychosis (CHR-P) criteria. The effectiveness of each available treatment for reducing attenuated positive ... -
Efficacy and acceptability of next step treatment strategies in adults with treatment-resistant major depressive disorder: protocol for systematic review and network meta-analysis
Cipriani, Andrea (2022-04)For major depression, a one-size-fits-all treatment does not exist. Patients enter a ‘trial-and-change’ algorithm in which effective therapies are subsequently applied. Unfortunately, an empirically based order of treatments ... -
Efficacy and acceptability of pharmacological and non-pharmacological interventions for non-specific chronic low back pain: a protocol for a systematic review and network meta-analysis.
Cipriani, Andrea (2020-06)Background Despite the enormous financial and humanistic burden of chronic low back pain (CLBP), there is little consensus on what constitutes the best treatment options from a multitude of competing interventions. The ... -
Efficacy and Effectiveness of Antipsychotics in Schizophrenia: Combining Evidence from Randomised Controlled Trials and Real-World.
Cipriani, Andrea (2023-10)Background: There is debate about the generalisability of results from randomised clinical trials (RCTs) to ‘real-world’ (RW) settings. Studying outcomes of treatments for schizophrenia can shed light on this issue and ... -
Estimating and visualising the trade-off between benefits and harms on multiple clinical outcomes in network meta-analysis
Cipriani, Andrea (2023-11)The relative treatment effects estimated from network meta-analysis can be employed to rank treatments from the most preferable to the least preferable option. These treatment hierarchies are typically based on ranking ... -
Ethical implications of poor comparative effectiveness evidence: obligations in industry-research partnerships
Cipriani, Andrea (2020-03)Which treatment is best for me? This question is at the centre of the clinical consultation. And yet, too often, the question is not answerable with available evidence on drugs and devices. The two Lancet Series papers on ... -
Examining the Effectiveness of Web-Based Interventions to Enhance Resilience in Health Care Professionals: Systematic Review
Henshall, Catherine; Ostinelli, Edoardo; Harvey, Jade; Cipriani, Andrea; Attenburrow, Mary-Jane (2022-07)Background: Internationally, the impact of continued exposure to workplace environmental and psychological stressors on health care professionals’mental health is associated with increased depression, substance misuse, ...