Browsing by Author "Cipriani, Andrea"
Now showing items 61-80 of 104
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Measuring Disturbance of the Endocannabinoid System in Psychosis A Systematic Review and Meta-analysis
Cipriani, Andrea; Lennox, Belinda; Godlewska, Beata R (2019-06)Importance: The endocannabinoid system (ECS) is a lipid-based endogenous signaling system. Its relevance to psychosis is through the association between cannabis use and the onset and course of illness and through the ... -
Modelling suicide in bipolar disorders: Limitations and opportunities
Smith, Katharine A; Cipriani, Andrea; Hawton, Keith (2018-07)Commentary on: Malhi GS, Outhred T, Das P et al. Modeling suicide in bipolar disorders. Bipolar Disord. 2018. In their paper in this issue, Malhi et al highlight a key clinical area; whilst suicide rates are increased in ... -
Natural language processing for structuring clinical text data on depression using UK-CRIS
De Crescenzo, Franco; Harvey, Jade; Cipriani, Andrea (2020-02)Background Utilisation of routinely collected electronic health records from secondary care offers unprecedented possibilities for medical science research but can also present difficulties. One key issue is that medical ... -
Network meta-analysis of antidepressants – Authors' reply
Cipriani, Andrea; Geddes, John R (2018-09-22)Comments on issues raised with Cipriani et al, 'Comparative efficacy and acceptability of 21 antidepressant drugs for the acute treatment of adults with major depressive disorder: a systematic review and network meta-analysis' ... -
No benefit from flexible titration above minimum licensed dose in prescribing antidepressants for major depression: systematic review
Cowen, Philip J; Cipriani, Andrea (2019-12)Background In fixed‐dose antidepressant trials, the lower range of the licensed dose achieves the optimal balance between efficacy and tolerability. Whether flexible upward titration while side‐effects permit provides ... -
One step closer to personalised prescribing of antidepressants: using real-world data together with patients and clinicians' preferences
Kernot, Catherine; Cipriani, Andrea (2019-07)Antidepressants for many decades have been shown to be an effective treatment for depressive disorder.1 Approximately 80% of people with depressive disorder in the UK will have been prescribed an antidepressant within the ... -
The Oxford study of Calcium channel Antagonism, Cognition, Mood instability and Sleep (OxCaMS): study protocol for a randomised controlled, experimental medicine study
Atkinson, Lauren Z; Colbourne, Lucy; Smith, Alexander L W; Harmer, Catherine J; Nobre, Anna C; Rendell, Jennifer; Jones, Helen; Hinds, Christopher; Mould, Arne; Tunbridge, Elizabeth; Cipriani, Andrea (2019-02)Background: The discovery that voltage-gated calcium channel genes such as CACNA1C are part of the aetiology of psychiatric disorders has rekindled interest in the therapeutic potential of L-type calcium channel (LTCC) ... -
Patient fibroblast circadian rhythms predict lithium sensitivity in bipolar disorder
Cipriani, Andrea; Attenburrow, Mary Jane; Harrison, Paul J; Goodwin, Guy M (2020-05)Bipolar disorder is a chronic neuropsychiatric condition associated with mood instability, where patients present significant sleep and circadian rhythm abnormalities. Currently, the pathophysiology of bipolar disorder ... -
Perinatal mental health and COVID-19: Navigating a way forward
Smith, Katharine A; Cipriani, Andrea (2022-11)The COVID-19 pandemic and its aftermath have increased pre-existing inequalities and risk factors for mental disorders in general, but perinatal mental disorders are of particular concern. They are already underdiagnosed ... -
Personalise antidepressant treatment for unipolar depression combining individual choices, risks and big data (PETRUSHKA): rationale and protocol
Cipriani, Andrea (2019-10)Introduction: Matching treatment to specific patients is too often a matter of trial and error, while treatment efficacy should be optimised by limiting risks and costs and by incorporating patients’ preferences. Factors ... -
Personalised treatment for cognitive impairment in dementia: development and validation of an artificial intelligence model
Cipriani, Andrea (2022-02)Donepezil, galantamine, rivastigmine and memantine are potentially effective interventions for cognitive impairment in dementia, but the use of these drugs has not been personalised to individual patients yet. We examined ... -
Pharmacological and non-pharmacological interventions for adults with ADHD: protocol for a systematic review and network meta-analysis
Cipriani, Andrea (2022-02)It is unclear how pharmacological and non-pharmacological interventions compare with each other in terms of efficacy and tolerability for core symptoms and additional problems in adults with attention-deficit/hyperactivity ... -
Pharmacological Treatments for Social Anxiety Disorder in Adults: A Systematic Review and Network Meta-Analysis
Cipriani, Andrea (2020-02)Objective: The aim of this paper was to provide a systematic review and update on the pharmacotherapy of social anxiety disorder (SAD), including the efficacy and tolerability of these agents, the ranking of interventions, ... -
Polyunsaturated fatty acids metabolism, purine metabolism and inosine as potential independent diagnostic biomarkers for major depressive disorder in children and adolescents
Cipriani, Andrea (2018-04-20)Major depressive disorder (MDD) in children and adolescents is a recurrent and disabling condition globally but its pathophysiology remains poorly elucidated and there are limited effective treatments available. We performed ... -
Predicting treatment effects in unipolar depression: A meta-review
Tomlinson, Anneka; Cipriani, Andrea (2020-08)There is increasing interest in clinical prediction models in psychiatry, which focus on developing multivariate algorithms to guide personalized diagnostic or management decisions. The main target of these models is the ... -
Pro-dopaminergic pharmacological interventions for anhedonia in depression: protocol for a living systematic review of human and non-human studies
Ostinelli, Edoardo; Browning, Michael; Cipriani, Andrea; Harmer, Catherine J (2023-10)Anhedonia is a key symptom of depression, and it has been suggested as a potential target for future individualised treatments. However, much is unknown about how interventions enhancing dopaminergic pathways may affect ... -
Producing and using timely comparative evidence on drugs: lessons from clinical trials for covid-19
Cipriani, Andrea (2020-10)Since the early days of the novel coronavirus outbreak, a record number of studies have been launched to test several repurposed and new medicines as potential treatments for covid-19 An analysis by the news organisation ... -
Promoting inclusivity by ensuring that all patients with mental health issues are offered research opportunities in the NHS
Henshall, Catherine; Jones, Helen; Smith, Tanya; Cipriani, Andrea (2022-01)Research-active clinical services have lower mortality rates and produce higher quality care outcomes, however, recruiting participants to clinical research in the National Health System (NHS) remains challenging.1 A recent ... -
Protocol for a systematic review and meta-analysis of coordinate-based network mapping of brain structure in bipolar disorder across the lifespan
Cipriani, Andrea (2023-10)Background: Studies about brain structure in bipolar disorder have reported conflicting findings. These findings may be explained by the high degree of heterogeneity within bipolar disorder, especially if structural ... -
Psychologic Treatment of Depression Compared With Pharmacotherapy and Combined Treatment in Primary Care: A Network Meta-Analysis
Cipriani, Andrea (2021-05)PURPOSE Most patients with depression are treated by general practitioners, and most of those patients prefer psychotherapy over pharmacotherapy. No network meta-analyses have examined the effects of psychotherapy compared ...