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    Valproate in dementia: time to move on? Commentary on…Cochrane Corner

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    Date
    2019-02
    Author
    Dhindsa, Amreek
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    Citation
    Amreek Dhindsa. Valproate in dementia: time to move on? Commentary on…Cochrane Corner. Advances (2019), vol. 25, 145–149 doi: 10.1192/bja.2019.8
    Abstract
    Baillon et al ’s Cochrane review included 430 participants with agitation in dementia from five randomised controlled trials. Overall, the reviewers found that valproate was no better than placebo for the treatment of agitation in people with dementia; however, the quality of the studies included was very variable. Adverse effects and events were higher in the treatment group compared with the controls, although these finding were largely based on low-quality data with incomplete reporting; thus, valproate’s safety profile is of concern. This review demonstrates that there is insufficient evidence to change current treatment guidelines.
    Description
    The article attached to this record is the Author(s) pre-/post- print version only. NOTE: this is not the version published in BJPsych Advances. Minor changes may have been made for publication. Eligible users can access the full text via NHS OpenAthens (login required)
    URI
    https://oxfordhealth-nhs.archive.knowledgearc.net/handle/123456789/759
    Published online at:
    https://doi:10.1192/bja.2019.8
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    • Dementia [30]
    • BJPsych Advances publications [15]

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