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Subjective cognitive complaints given in questionnaire: relationship with brain structure, cognitive performance and self-reported depressive symptoms in a 25-year retrospective cohort study
(2020-07)
Subjective cognitive complaints are common but it is unclear whether they indicate an underlying pathological process or reflect affective symptoms.
Method:800 community-dwelling older adults were drawn from the Whitehall ...
Effect of the NMDA receptor partial agonist, d-cycloserine, on emotional processing and autobiographical memory
(2020-04)
Background: Studies suggest that d-cycloserine (DCS) may have antidepressant potential through its interaction with the glycine site of the N-Methyl-D-aspartate receptor (NMDAR); however clinical evidence of DCS’s efficacy ...
The Oxford study of Calcium channel Antagonism, Cognition, Mood instability and Sleep (OxCaMS): study protocol for a randomised controlled, experimental medicine study
(2019-02)
Background:
The discovery that voltage-gated calcium channel genes such as CACNA1C are part of the aetiology of psychiatric disorders has rekindled interest in the therapeutic potential of L-type calcium channel (LTCC) ...
The effect of sertraline on emotional processing: secondary analyses of the PANDA randomised controlled trial
(2021-01)
Background. According to the cognitive neuropsychological model, antidepressants reduce
symptoms of depression and anxiety by increasing positive relative to negative information processing. Most studies of whether ...