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Cognition in Mood Disorders
(2020-01)
Mood disorders are common, complex, and one of the main causes of morbidity worldwide (1).
There has been an increasing recognition that cognitive dysfunction is a central aspect of most
mood disorders, as well as being ...
A single administration of ‘microbial’ D-alanine to healthy volunteers augments reaction to negative emotions: a comparison with D-serine
(2020-03)
Background Activation of the glutamate N-methyl-D-Aspartate receptor (NMDAR) with its co-agonist D-serine has been shown to improve subjective mood in healthy volunteers. D-alanine is another potent NMDAR co-agonist which ...
Precision biomarkers for mood disorders based on brain imaging
(2020-10)
Mood disorders are a global public health problem because of their high prevalence, chronicity, and recurrence throughout the lifespan as well as increased risk of mortality.123 They also impose a heavy economic burden on ...
Catechol-O-methyltransferase activity does not influence emotional processing in men
(2022-04)
Background: Catechol-O-methyltransferase (COMT) regulates cortical dopaminergic transmission and prefrontal-dependent cognitive function. However, its role in other cognitive processes, including emotional processing, is ...
Déjà-vu? Neural and behavioural effects of the 5-HT 4 receptor agonist, prucalopride, in a hippocampal-dependent memory task
(2021-10)
Cognitive deficits commonly accompany psychiatric disorders but are often underrecognised, and difficult to treat. The 5-HT4 receptor is a promising potential treatment target for cognitive impairment because in animal ...
Translating the promise of 5HT4 receptor agonists for the treatment of depression
(2020-02)
Animal experimental studies suggest that 5-HT4 receptor activation holds promise as a novel
target for the treatment of depression and cognitive impairment. 5-HT4 receptors are postsynaptic
receptors that are located in ...