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A Dissociation of the Acute Effects of Bupropion on Positive Emotional Processing and Reward Processing in Healthy Volunteers
(2018-10)
Background: Previous research indicates that antidepressants can restore the balance between negative and positive emotional processing early in treatment, indicating a role of this effect in later mood improvement. However, ...
Predicting Treatment Response to Antidepressant Medication Using Early Changes in Emotional Processing.
(2019-01)
Antidepressants must be taken for weeks before response can be assessed with many patients not responding to the first medication prescribed. This often results in long delays before effective treatment is started. ...
Symptom trajectories in discontinuation trials.
(2017-02)
Many patients with clinical depression, particularly those with recurrent illness, are treated with maintenance antidepressants after an acute-phase response. But how effective is this approach? The effectiveness of ...
An Experimental Medicine Investigation of the Effects of Subacute Pramipexole Treatment on Emotional Information Processing in Healthy Volunteers
(2021-08)
Treatment with the dopamine D2/D3 receptor agonist pramipexole has demonstrated
promising clinical effects in patients with depression. However, the mechanisms through which
pramipexole might alleviate depressive symptoms ...
An Experimental Medicine Investigation of the Effects of Subacute Pramipexole Treatment on Emotional Information Processing in Healthy Volunteers
(2021-08)
Treatment with the dopamine D2/D3 receptor agonist pramipexole has demonstrated
promising clinical effects in patients with depression. However, the mechanisms through which
pramipexole might alleviate depressive symptoms ...
Predicting treatment response in depression: the role of anterior cingulate cortex
(2018)
Background:
Identification of biomarkers predicting therapeutic outcome to antidepressant treatment is one of the most important tasks in current research because it may transform the lengthy process of finding the right ...
Accuracy in recognising happy facial expressions is associated with antidepressant response to a NOP receptor antagonist but not placebo treatment
(2021-10)
Background: Clinical trials with putative antidepressants can be difficult to execute as it can take up to 8 weeks before differences emerge between drug and placebo, and long expensive trials often fail. Implementation ...
Fifty years on: Serotonin and depression
(2023-03)
It has been over 50 years since the original serotonin hypothesis was proposed by the British Psychiatrist Alec Coppen. Recently, some authors have questioned the validity of the hypothesis. In this narrative review, we ...
Pramipexole for the Treatment of Depression: Efficacy and Mechanisms
(2023-11)
Dopaminergic mechanisms are a plausible treatment target for patients with clinical depression but are relatively underexplored in conventional antidepressant medications. There is continuing interest in the potential ...